| Intracarotid abciximab injection to abort impending ischemic stroke during carotid angioplasty. | |
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MedLine Citation:
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PMID: 11385208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Abciximab, a platelet glycoprotein IIb/IIIa receptor antagonist, prevents ischemic complications during percutaneous transluminal coronary angioplasty and was recently shown to open occluded vessels in patients with acute myocardial infarction when used alone or in combination with other thrombolytic agents. In an animal model of arterial thrombosis, abciximab was found to be safe and effective for the prevention of carotid artery thrombosis. However, the safety and efficacy of abciximab in the treatment of acute ischemic cerebrovascular events is unknown at present. CASE DESCRIPTION: We describe 3 patients who experienced ischemic cerebrovascular events with symptoms involving the middle cerebral artery territory while undergoing percutaneous angioplasty and stenting to their internal carotid arteries. Abciximab was administered to each patient within 10 min of symptom onset as a bolus (0.25 mg/kg) into the ipsilateral common carotid artery followed by continuous intravenous infusion (9 microg/min) for 12 h. All patients' symptoms resolved completely (by 25 min, 40 min and 5 h, respectively) with no further neurological complications. CONCLUSIONS: Our preliminary observation suggests that abciximab may improve neurological outcome following middle cerebral artery ischemic events associated with carotid angioplasty and stenting. Large prospective studies are warranted to establish the safety and efficacy of abciximab in acute ischemic stroke, either as a primary treatment modality or an adjunct to carotid angioplasty and stenting. |
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Authors:
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D S Ho; Y Wang; M Chui; Y Wang; S L Ho; R T Cheung |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cerebrovascular diseases (Basel, Switzerland) Volume: 11 ISSN: 1015-9770 ISO Abbreviation: Cerebrovasc. Dis. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-05-31 Completed Date: 2002-10-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9100851 Medline TA: Cerebrovasc Dis Country: Switzerland |
Other Details:
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Languages: eng Pagination: 300-4 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel. |
Affiliation:
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Division of Cardiology, Queen Mary Hospital Department of Medicine, The University of Hong Kong, Hong Kong. dswho@hku.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty* Antibodies, Monoclonal / administration & dosage, therapeutic use* Brain Ischemia / prevention & control* Carotid Artery, Common / surgery* Cerebral Angiography Female Humans Immunoglobulin Fab Fragments / administration & dosage, therapeutic use* Injections, Intra-Arterial Intraoperative Complications / prevention & control Male Middle Cerebral Artery / pathology Platelet Aggregation Inhibitors / administration & dosage, therapeutic use* Stents Stroke / prevention & control* Tomography, Emission-Computed, Single-Photon |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Immunoglobulin Fab Fragments; 0/Platelet Aggregation Inhibitors; 143653-53-6/abciximab |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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