| Intracardiac echogenic focus and trisomy 21 in a population previously evaluated by first-trimester combined screening. | |
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MedLine Citation:
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PMID: 20521868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the relation between intracardiac echogenic focus (ICEF) and trisomy 21 in a population of fetuses previously evaluated by first-trimester combined screening. DESIGN: Prospective study to evaluate the prevalence of trisomy 21 for four groups of pregnancies: those with isolated ICEF, those with ICEF and positive first-trimester combined screening, those with ICEF and other ultrasound markers, and those with ICEF, positive first-trimester combined screening and other ultrasound markers. SETTING: Teaching hospital. POPULATION: A total of 7,118 fetuses received first-trimester combined screening and a second-trimester fetal anatomical scan. METHODS: Amniocentesis for karyotyping was offered for those with positive result of first-trimester combined screening, and for those with the diagnosis of ICEF or other fetal chromosomal aneuploidy ultrasound markers in mid-trimester detailed fetal anatomical scans. MAIN OUTCOME MEASURES: The prevalence of trisomy 21 in each group. RESULTS: For the entire study population, 25 trisomy 21 cases were diagnosed prenatally (prevalence, 0.35%). Among fetuses with positive first-trimester combined screening results, the likelihood ratio of trisomy 21 was significantly increased for those with, as compared to without, ICEF (3.5 vs. 0.80, p = 0.012). However, among fetuses with negative first-trimester combined screening results, the likelihood ratios of trisomy 21 did not differ significantly between those with and without ICEF. CONCLUSION: In pregnancies complicated by isolated ICEF but lacking additional anomalies on ultrasonographic examination and exhibiting negative first-trimester combined screening results, fetal karyotyping is not indicated. |
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Authors:
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Shang-Yu Huang; Sheng-Wen Shaw; Ho-Yen Cheuh; Po-Jen Cheng |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 1017-23 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan, Taiwan, ROC. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cardiomyopathies / ultrasonography Down Syndrome / diagnosis* Female Fetal Heart / ultrasonography* Heart Ventricles / embryology, ultrasonography Humans Likelihood Functions Middle Aged Papillary Muscles / ultrasonography Pregnancy Pregnancy Trimester, First* Prevalence Prospective Studies Ultrasonography, Prenatal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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