| Intrabronchial surfactant application in cases of inhalation injury: first results from patients with severe burns and ARDS. | |
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MedLine Citation:
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PMID: 9677021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Damage to the respiratory tract caused by inhalation of toxic products of combustion with subsequent development of an acute respiratory distress syndrome (ARDS) is one of the main causes of death in burn patients. Treatment with an exogenous surfactant is a therapeutic option for which there has previously been no empirical data. We report on four severely burned patients with deep partial thickness and full thickness burns of between 40 and 70 per cent body surface area (BSA), and with inhalation injury complicated by ARDS. These patients were treated once or more than once with bovine surfactant replacement (Alveofact). In addition to biophysical and biochemical analysis, the influence of this substance on oxygenation and lung function were evaluated. After the limits of mechanical ventilation had been reached, bronchoscopic intrabronchial administration of surfactant was followed by temporarily improved gas exchange with an increase in arterial O2 partial pressure (PaO2), accompanied by a reduction in inspiratory O2 concentration (FiO2), and also improved lung compliance. All the patients survived in spite of an initially unfavourable prognosis. Replacement of exogenous surfactant in the treatment of inhalation traumatized severe burn patients with ARDS appears to show considerable promise as an approach to improving the survival chances of these high-risk patients. |
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Authors:
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N Pallua; K Warbanow; E M Noah; H G Machens; C Poets; W Bernhard; A Berger |
Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article |
Journal Detail:
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Title: Burns : journal of the International Society for Burn Injuries Volume: 24 ISSN: 0305-4179 ISO Abbreviation: Burns Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-09-21 Completed Date: 1998-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8913178 Medline TA: Burns Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 197-206 Citation Subset: IM |
Affiliation:
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Clinic for Plastic, and Reconstructive Surgery, Burn Centre at University Hospital RTWH Aachen, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bronchi Burns, Inhalation / complications, drug therapy*, physiopathology Female Follow-Up Studies Humans Instillation, Drug Male Middle Aged Pulmonary Surfactants / administration & dosage*, therapeutic use Respiratory Distress Syndrome, Adult / complications, drug therapy*, physiopathology Respiratory Function Tests Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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