Document Detail


Intraarterial protein delivery via intimally-adherent bilayer hydrogels.
MedLine Citation:
PMID:  10640658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial structure plays an important role in drug delivery from intraarterial depots. The internal elastic lamina forms a major diffusive resistance to the transport of macromolecular drugs from intimally-adherent hydrogel depots to the arterial media. The objectives of this study were to develop an approach by which to form a bilayer hydrogel depot with a higher permeability intimally-adherent layer, containing the drug, and a lower permeability luminal layer, and to evaluate ex vivo whether this luminal layer could enhance the delivery of a protein to the arterial media. Sequential interfacial photopolymerization of polyethyleneglycol diacrylate precursors (molecular weight 4000 for the luminal layer, 10,000 for the intimal layer) with eosin Y and triethanolamine as an initiation system was employed to form these bilayer hydrogels. Horseradish peroxidase was used as a model protein, and delivery to the arterial media was measured in rat carotid arteries ex vivo. The lower permeability luminal layer served to enhance delivery of the model protein into the arterial media for delivery periods at least up to 72 h. Thus, it was possible to compensate for the diffusional resistance of the internal elastic lamina on the one side of the hydrogel depot with a second diffusional resistance on the other side of the hydrogel.
Authors:
Y An; J A Hubbell
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  64     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-30     Completed Date:  2000-03-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-15     Citation Subset:  IM    
Affiliation:
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carotid Arteries / physiology
Delayed-Action Preparations / pharmacokinetics*
Drug Delivery Systems / methods*
Eosine Yellowish-(YS) / chemistry
Ethanolamines / chemistry
Horseradish Peroxidase / administration & dosage*
Hydrogels / pharmacokinetics*
Infusions, Intra-Arterial
Permeability
Polyethylene Glycols / chemistry
Polymers / pharmacokinetics*
Rats
Time Factors
Grant Support
ID/Acronym/Agency:
HL 56297/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Ethanolamines; 0/Hydrogels; 0/Polyethylene Glycols; 0/Polymers; 102-71-6/triethanolamine; 17372-87-1/Eosine Yellowish-(YS); EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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