Document Detail

Intraarterial propofol is not directly toxic to vascular endothelium.
MedLine Citation:
PMID:  1599119     Owner:  NLM     Status:  MEDLINE    
To determine if accidental intraarterial injection of propofol results in vascular damage, the effect of bolus administration of propofol on vascular smooth muscle and the endothelium was investigated using the isolated rabbit ear artery. Ear artery segments, removed from urethane anesthetized rabbits, were perfused with Krebs solution (1 ml.min-1) and pressurized to 60 mmHg before being constricted with extraluminal norepinephrine (1.8-4.2 x 10(-6) M). The external diameter of the vessel was measured by an array of light-dependent diodes. Functional responsiveness was determined by the degree of constriction to norepinephrine and the subsequent dilatation of the artery to intraluminal acetylcholine (2 x 10(-6) M) and glyceryl trinitrate (2 x 10(-6) M), and by the myogenic reactivity to a pressure increase from 60 to 100 mmHg. These responses were measured before and after perfusion with 1% propofol for 120 s. Administration of propofol did not result in any vasoactivity nor did it increase the sensitivity to norepinephrine. Vessels maintained their capacity to dilate to both agents, while the myogenic activity was unaffected. Histologic examination of the propofol exposed vessels showed no changes to smooth muscle structure, and the endothelial layer remained intact.
R D MacPherson; R L Rasiah; L J McLeod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anesthesiology     Volume:  76     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-09     Completed Date:  1992-07-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  967-71     Citation Subset:  AIM; IM    
Department of Physiology, University of Tasmania, Australia.
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MeSH Terms
Ear / blood supply
Endothelium, Vascular / drug effects*
Injections, Intra-Arterial
Muscle, Smooth, Vascular / drug effects*
Propofol / administration & dosage*,  toxicity
Reg. No./Substance:

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