Document Detail


Intraarterial doxorubicin infusion treatment with and without occlusion of the renal artery in rabbit renal VX-2 carcinoma. Establishing an animal model.
MedLine Citation:
PMID:  2958065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this investigation was to establish an animal model for studying fractionated intraarterial treatment of a rabbit kidney VX-2 carcinoma. As repeated catheterizations and drug infusions may cause vascular lesions, we wanted to find whether the rabbit renal artery could be catheterized several times within a short period of time with acceptable iatrogenic vascular trauma. Each of 3 groups of rabbits with implanted renal VX-2 carcinoma were treated 3 times with either 1) temporary renal artery occlusion combined with infusion (occlusion infusion) of a) physiologic saline (OIS) or b) doxorubicin (OID), or 2) with renal artery infusion of doxorubicin. OID was administered in 20 of 21 attempts, OIS in 21 of 24, and infusion of doxorubicin in 20 of 21 attempts. Renal arterial spasm was seen in 5 of 22 rabbits, rarely at the first catheterization, more frequently during the second and third. Permanent iatrogenic vascular trauma occurred in 4 of 15 rabbits after the second and third occlusion infusion. We conclude that the rabbit kidney with implanted VX-2 carcinoma may be a useful model for testing fractionation schemes for multiple intraarterial infusions of antineoplastic drugs.
Authors:
G Gadeholt; J H Göthlin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  28     ISSN:  0284-1851     ISO Abbreviation:  Acta Radiol     Publication Date:    1987 Jul-Aug
Date Detail:
Created Date:  1987-11-17     Completed Date:  1987-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  467-71     Citation Subset:  IM    
Affiliation:
Department of Diagnostic Radiology, University of Rochester Medical Center, New York.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma / therapy*
Catheterization / adverse effects
Cell Line
Constriction, Pathologic
Disease Models, Animal
Doxorubicin / administration & dosage*,  adverse effects
Fluoroscopy
Infusions, Intra-Arterial / adverse effects
Kidney Neoplasms / therapy*
Male
Rabbits
Renal Artery / radiography
Spasm / etiology
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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