| Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent age group. | |
| | |
MedLine Citation:
|
PMID: 1884535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sixty patients with extremity osteosarcoma were treated with intraarterial cisplatin. This was followed by surgical resection (amputation or limb salvage) and postoperative adjuvant chemotherapy utilizing two different protocols. Seventy-five percent of patients achieved an initial response. Overall disease-free survival was 58%. The number of patients treated with limb-salvage surgery gradually increased to the extent that 80% of newly-registered patients achieved a response and were subjected to limb salvage. Disease-free survival was 48% in amputation and 68% in limb salvage. The only factors found to have prognostic significance in determining disease-free survival were extent of tumor destruction induced by preoperative chemotherapy and tumor size. |
| | |
Authors:
|
N Jaffe; D Smith; M R Jaffe; M Hudson; H Carrasco; S Wallace; A K Raymond; A Ayala; J Murray; R Robertson |
Related Documents
:
|
20636985 - Potential risks, prognostic indicators, and diagnostic and treatment modalities affecti... 10499645 - Inhalation chemotherapy for macroscopic primary or metastatic lung tumors: proof of pri... 16426175 - Evaluation of prognostic factors associated with outcome in dogs with multiple cutaneou... 11397315 - Retrobulbar tumors in dogs and cats: 25 cases. 1998475 - Prognostic factors in primary retroperitoneal soft-tissue sarcomas. 15748465 - Weekly docetaxel/carboplatin as primary systemic therapy for her2-negative locally adva... |
Publication Detail:
|
Type: Clinical Trial; Journal Article |
Journal Detail:
|
Title: Clinical orthopaedics and related research Volume: - ISSN: 0009-921X ISO Abbreviation: Clin. Orthop. Relat. Res. Publication Date: 1991 Sep |
Date Detail:
|
Created Date: 1991-10-10 Completed Date: 1991-10-10 Revised Date: 2005-03-03 |
Medline Journal Info:
|
Nlm Unique ID: 0075674 Medline TA: Clin Orthop Relat Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 15-21 Citation Subset: AIM; IM |
Affiliation:
|
Division of Pediatrics, University of Texas M.D. Anderson Caner Center, Houston 77030. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Amputation / standards Bone Neoplasms / mortality, pathology, therapy* Child Child, Preschool Cisplatin / administration & dosage, therapeutic use* Clinical Protocols / standards Combined Modality Therapy Humans Injections, Intra-Arterial Life Tables Neoplasm Staging Osteosarcoma / mortality, pathology, therapy* Osteotomy / standards Preoperative Care / methods, standards Prognosis Remission Induction / methods Survival Rate Texas / epidemiology |
| Chemical | |
Reg. No./Substance:
|
15663-27-1/Cisplatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pelvic osteosarcoma. Resection, reconstruction, local control, and survival statistics.
Next Document: Comparative aspects of osteosarcoma. Dog versus man.