| Intraarterial thrombolysis and stent placement for acute basilar artery occlusion. | |
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MedLine Citation:
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PMID: 20688533 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study retrospectively the prognostic factors for acute basilar artery occlusion treated with intraarterial thrombolysis and stent placement. MATERIALS AND METHODS: Within 3-48 hours of disease onset, 52 patients with basilar artery occlusion were treated with emergency intraarterial thrombolysis with recombinant tissue plasminogen activator (rtPA) or urokinase (UK) or intraarterial thrombolysis combined with stent placement. Sixteen patients simultaneously received stent placement for the partial recanalization of basilar artery occlusion after intraarterial thrombolysis. The National Institutes of Health Stroke Scale (NIHSS) scores and the modified Rankin Scale (mRS) scores of the patients were estimated. RESULTS: A favorable clinical outcome occurred in 22 patients (42.3%), and 20 patients (38.5%) died. The survival rate was 61.5% (32 patients). Successful recanalization of basilar artery occlusion was achieved in 24 patients (46.2%), and partial recanalization was achieved in 16 patients (30.7%). The rate of recanalization was 76.9%. NIHSS scores less than 14, treatment time window less than 24 hours, and a good recanalization were markedly correlated with good clinical prognosis. NIHSS scores less than 14 and treatment time window less than 24 hours were significantly correlated with recanalization. NIHSS scores less than 14 and good recanalization could act as independent predictors for clinical prognosis. CONCLUSIONS: NIHSS scores less than 14 on admission and successful recanalization can predict favorable outcome for patients with basilar artery occlusion. This study shows that intraarterial thrombolysis and stent placement may be a useful treatment for acute basilar artery occlusion. |
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Authors:
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Yao-Yu Yu; Le Niu; Li Gao; Zhen-Wei Zhao; Jian-Ping Deng; You-Zhi Qu; De-Rang Jiao; Jin-Qing Yang; Guo-Dong Gao |
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Publication Detail:
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Type: Journal Article Date: 2010-08-04 |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 21 ISSN: 1535-7732 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1359-63 Citation Subset: IM |
Copyright Information:
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Copyright 2010 SIR. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neurosurgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an 710038, China. yuyaoyu666@yahoo.com.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Angioplasty, Balloon / adverse effects, instrumentation*, mortality China Combined Modality Therapy Disability Evaluation Female Fibrinolytic Agents / administration & dosage*, adverse effects Humans Injections, Intra-Arterial Logistic Models Male Middle Aged Odds Ratio Recombinant Proteins / administration & dosage Retrospective Studies Risk Assessment Risk Factors Severity of Illness Index Stents* Stroke / drug therapy, mortality, therapy* Survival Rate Thrombolytic Therapy* / adverse effects, mortality Time Factors Tissue Plasminogen Activator / administration & dosage Treatment Outcome Urokinase-Type Plasminogen Activator / administration & dosage Vertebrobasilar Insufficiency / drug therapy, mortality, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Recombinant Proteins; EC 3.4.21.68/Tissue Plasminogen Activator; EC 3.4.21.73/Urokinase-Type Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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