| Intraarterial MR angiography and DSA in patients with peripheral arterial occlusive disease: prospective comparison. | |
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MedLine Citation:
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PMID: 16641335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To prospectively evaluate the accuracy of intraarterial magnetic resonance (MR) angiography in the depiction of significant stenoses and occlusions, with intraarterial digital subtraction angiography (DSA) serving as the reference standard. MATERIALS AND METHODS: Approval of the local ethics committee and informed consent were obtained. Twenty patients (11 men; nine women; age range, 48-86 years; mean age, 69.5 years+/-11.2 [standard deviation]) with symptomatic peripheral arterial occlusive disease (PAOD) were prospectively enrolled. After percutaneous transluminal angioplasty (PTA), intraarterial MR angiography was performed in the thigh and the calf with a 1.5-T MR imager in two consecutive runs. Intraarterial MR angiography was performed with a low-dose injection protocol (ie, two 20-mL injections of a 50-mmol gadolinium-based contrast agent). Moderate stenoses (luminal narrowing<or=50%), significant stenoses (luminal narrowing 51%-99%), and occlusions (luminal narrowing of 100%) were identified on MR angiograms, which were compared with intraarterial DSA images. Intraarterial MR angiograms were analyzed for imaging artifacts. Sensitivity, specificity, accuracy, and positive and negative predictive values of intraarterial MR angiography with intraarterial DSA were determined for characterization of significant stenoses (>50%) or vessel occlusions; 95% confidence intervals (CIs) were calculated for sensitivity and specificity. RESULTS: Intraarterial DSA revealed 78 moderate stenoses, 57 significant stenoses, and 28 occlusions. Sensitivity, specificity, and accuracy of intraarterial MR angiography in the characterization of significant stenoses or occlusions were 92% (95% CI: 72%, 99%), 94% (95% CI: 82%, 98%), and 93%, respectively, in femoropopliteal arteries and 93% (95% CI: 83%, 98%), 71% (95% CI: 51%, 86%), and 86%, respectively, in infrapopliteal arteries. The main artifact observed with intraarterial MR angiography was venous contamination (12%). CONCLUSION: Intraarterial MR angiography is an accurate method used to depict significant stenoses and occlusions in lower extremity arteries with a low-dose injection protocol. |
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Authors:
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Rolf W Huegli; Markus Aschwanden; Georg Bongartz; Kurt Jaeger; Hans-Georg Heidecker; Christoph Thalhammer; Anja-Carina Schulte; Claus Hashagen; Augustinus L Jacob; Deniz Bilecen |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-04-26 |
Journal Detail:
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Title: Radiology Volume: 239 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-22 Completed Date: 2006-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 901-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) RSNA, 2006. |
Affiliation:
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Department of Radiology, University Hospital of Basel, Petersgraben 4, 4031 Basel, Switzerland. rhuegli@uhbs.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiography, Digital Subtraction / methods* Angioplasty, Balloon Arterial Occlusive Diseases / diagnosis*, radiography Artifacts Constriction, Pathologic / diagnosis, radiography Contrast Media Female Femoral Artery / pathology Gadolinium DTPA / diagnostic use Humans Image Processing, Computer-Assisted / methods Leg / blood supply Magnetic Resonance Angiography / methods* Male Middle Aged Peripheral Vascular Diseases / diagnosis*, radiography Popliteal Artery / pathology Predictive Value of Tests Prospective Studies Sensitivity and Specificity Thigh / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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