| Intra-uterine bupivacaine and levobupivacaine. | |
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MedLine Citation:
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PMID: 20219000 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The study aimed to compare the effect of intrauterine bupivacaine and levobupivacaine with placebo in reducing the post-procedure discomfort owing to pain caused by suction endometrial sampling. METHODS: This study was conducted on randomly selected 45 women with abnormal uterine bleeding and who had undergone outpatient hysteroscopy and endometrial biopsy under sedation with propofol 0.5 mg/kg. The study was performed using 5 mL of bupivacaine 0.5% (Group B, n = 15) or levobupivacaine 0.5% (Group L, n = 15) or placebo solution (Group C, n = 15) intrauterine via a catheter over a 5 min period after suction endometrial sampling. The number of patients with visual analogue scale >3, total postoperative analgesic requirements, satisfaction of patients and adverse events were measured. Nonparametric and parametric data were analysed using Kruskal-Wallis and one-way anova tests respectively. RESULTS: Women in Groups L and B had statistically significantly less pain than the women in Group C (P = 0.03). When compared with placebo, five ml of bupivacaine 0.5% and levobupivacaine 0.5% respectively were recorded to decrease the incidence of postoperative analgesic consumption from 41 to 35% (P = 0.01). The satisfaction score of the patients in Group L was significantly higher than that of the patients in Group C (P = 0.03). CONCLUSION: Intrauterine levobupivacaine or bupivacaine is effective in decreasing the pain associated with the endometrial biopsy and curettage under propofol sedation. |
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Authors:
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Ayse Mizrak; Gurol M Ugur; Pinar Erdaloglu; Ozcan Balat; Unsal Oner |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Australian & New Zealand journal of obstetrics & gynaecology Volume: 50 ISSN: 1479-828X ISO Abbreviation: Aust N Z J Obstet Gynaecol Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0001027 Medline TA: Aust N Z J Obstet Gynaecol Country: Australia |
Other Details:
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Languages: eng Pagination: 65-9 Citation Subset: IM |
Affiliation:
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Gaziantep University School of Medicine, Turkey. aysemizrak@mynet.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Local / administration & dosage* Biopsy, Needle / adverse effects* Bupivacaine / administration & dosage*, analogs & derivatives Double-Blind Method Endometrium / surgery* Female Humans Middle Aged Pain, Postoperative / prevention & control* Placebos |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Placebos; 0/levobupivacaine; 2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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