| Intra-portal injection of 400- microm microcapsules in a large-animal model. | |
| | |
MedLine Citation:
|
PMID: 12819871 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To date, encapsulated grafts have usually been implanted in the peritoneal cavity. This site is, however, not ideal, mainly because of its low blood supply. We have investigated the feasibility of intra-portal injection of (400 microm) microcapsules in the pig. Ten-thousand microcapsules per kilogram body weight were injected into six Large White pigs. Portal pressure, various biological tests, portographies and liver histology were recorded before and at various time points after injection. As a result, portal pressure increased after injection (15+/-2.3 vs 8.7+/-1.7 mmHg) but remained within an acceptable range (<20 mmHg) and returned to normal values at 3 months (8.5+/-3.7 mmHg). During the 3-month follow up, liver function and liver tests remained stable. Portographies showed a homogenous implantation of the capsule, with the portal flow always directed to the liver. At histological examination after 3 months the capsules demonstrated various degrees of fibrosis. We can thus conclude that these results demonstrate that intra-portal injection of microcapsules is feasible in a large-animal model. Hemodynamic, biological and radiological results are similar to those observed in clinical free-islet transplantation. |
| | |
Authors:
|
Christian Toso; José Oberholzer; Ion Ceausoglu; Frédéric Ris; Bertrand Rochat; Annemie Rehor; Pascal Bucher; Christine Wandrey; Ute Schuldt; Jacques Belenger; Domenico Bosco; Philippe Morel; David Hunkeler |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-03-20 |
Journal Detail:
|
Title: Transplant international : official journal of the European Society for Organ Transplantation Volume: 16 ISSN: 0934-0874 ISO Abbreviation: Transpl. Int. Publication Date: 2003 Jun |
Date Detail:
|
Created Date: 2003-06-23 Completed Date: 2004-03-02 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8908516 Medline TA: Transpl Int Country: Germany |
Other Details:
|
Languages: eng Pagination: 405-10 Citation Subset: IM |
Affiliation:
|
Division d'Investigations Chirurgicales, Clinique de Chirurgie Digestive et Unité de Transplantation, Hôpital Universitaire, 24 Rue Micheli-du-Crest, 1211 Geneva, Switzerland. christian.toso@hcuge.ch |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Capsules / administration & dosage* Feasibility Studies Female Follow-Up Studies Hemodynamics Injections, Intravenous Liver / pathology Microspheres* Portal Pressure Portal Vein* Portography Swine |
| Chemical | |
Reg. No./Substance:
|
0/Capsules |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Induction of specific stress response increases resistance of rat liver allografts to cold ischemia ...
Next Document: Outcome of renal transplantation in patients with systemic lupus erythematosus.