Document Detail

Intra-operative patient-controlled sedation and patient attitude to control. A crossover comparison of patient preference for patient-controlled propofol and propofol by continuous infusion.
MedLine Citation:
PMID:  8179132     Owner:  NLM     Status:  MEDLINE    
Intra-operative patient controlled sedation with propofol (bolus dose 18 mg over 5.4 s; lockout period 1 min) has been compared to continuous propofol infusion (3.6 in a randomised crossover study of 38 ASA 1 or 2 day surgery patients undergoing two-stage bilateral extraction of third molar teeth under local anaesthesia (76 procedures). Mean (SD) propofol used ( was less with patient-controlled sedation (2.39 (1.28) than with the infusion (2.58 (0.84)) but the difference was not statistically significant. There were only minor differences between the methods in postoperative recovery of cognitive function and no differences for patient cooperation and surgeon's satisfaction with sedation. Patient-controlled sedation was preferred by 19 patients, continuous infusion by 10, with nine indifferent. Preferences, expressed as mild, moderate or strong, were significantly stronger for patient-controlled sedation (p < 0.05). Sedation was no deeper than eyelid closure with response to command in all 76 procedures. This level was reached in all 38 infusion cases but in only 26 cases with patient-controlled sedation, where 12 patients remained less sedated (p < 0.01). Patient-controlled sedation with propofol provided safe sedation and was strongly preferred over the infusion by a large proportion of patients.
G A Osborne; G E Rudkin; D A Jarvis; I G Young; J Barlow; P I Leppard
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  49     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-06-06     Completed Date:  1994-06-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  287-92     Citation Subset:  AIM; IM    
Department of Anaesthesia and Intensive Care, Royal Adelaide Hospital, South Australia.
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MeSH Terms
Anesthesia, Dental / methods*
Anesthesia, Intravenous
Conscious Sedation / psychology*
Infusions, Intravenous
Patient Satisfaction
Propofol / administration & dosage*
Self Administration
Tooth Extraction*
Reg. No./Substance:

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