| Intra-operative parathyroid identification using methylene blue in parathyroid surgery. | |
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MedLine Citation:
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PMID: 17879694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification. |
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Authors:
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Nancy Han; Jeffrey M Bumpous; Richard E Goldstein; Muffin M Fleming; Michael B Flynn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American surgeon Volume: 73 ISSN: 0003-1348 ISO Abbreviation: Am Surg Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-09-20 Completed Date: 2007-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370522 Medline TA: Am Surg Country: United States |
Other Details:
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Languages: eng Pagination: 820-3 Citation Subset: IM |
Affiliation:
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Division of Surgical Oncology, University of Louisville School of Medicine, Department of Surgery, Louisville, Kentucky, 40202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enzyme Inhibitors
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administration & dosage,
diagnostic use* Follow-Up Studies Humans Hyperparathyroidism, Primary / pathology, surgery* Infusions, Intravenous Intraoperative Care / methods* Length of Stay Methylene Blue / administration & dosage, diagnostic use* Parathyroid Glands / pathology*, surgery Parathyroidectomy / methods* Reproducibility of Results Retrospective Studies Staining and Labeling / methods* Surgical Procedures, Minimally Invasive Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 61-73-4/Methylene Blue |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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