Document Detail

Intra-operative parathyroid identification using methylene blue in parathyroid surgery.
MedLine Citation:
PMID:  17879694     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine the value of intra-operative methylene blue (MB) during parathyroid surgery. We did a retrospective study of 473 patients after initial exploration for previously untreated symptomatic primary hyperparathyroidism. Procedural and post procedural data were collected on four groups of patients: minimally invasive parathyroidectomy with MB (n = 147), and without MB (n = 205), bilateral parathyroid exploration with intra-operative parathormone assay with MB (n = 56), and without MB (n = 65). Length of surgery was shorter for patients explored with MB (P = 0.026). For the minimally invasive parathyroidectomy group, the difference between the MB and non-MB groups was seven minutes. Twelve minutes was the difference between the MB and non-MB intra-operative parathormone assay groups. Length of stay, local complications, and correction of hypercalcemia after parathyroidectomy were not significantly affected by the use of MB. Systemic complications were lower in the MB groups. Aside from a statistically significant, but quantitatively minimal decrease in the length of surgery, no consistent benefit was identified with the use of MB for intra-operative parathyroid identification.
Nancy Han; Jeffrey M Bumpous; Richard E Goldstein; Muffin M Fleming; Michael B Flynn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American surgeon     Volume:  73     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-20     Completed Date:  2007-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  820-3     Citation Subset:  IM    
Division of Surgical Oncology, University of Louisville School of Medicine, Department of Surgery, Louisville, Kentucky, 40202, USA.
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MeSH Terms
Enzyme Inhibitors / administration & dosage,  diagnostic use*
Follow-Up Studies
Hyperparathyroidism, Primary / pathology,  surgery*
Infusions, Intravenous
Intraoperative Care / methods*
Length of Stay
Methylene Blue / administration & dosage,  diagnostic use*
Parathyroid Glands / pathology*,  surgery
Parathyroidectomy / methods*
Reproducibility of Results
Retrospective Studies
Staining and Labeling / methods*
Surgical Procedures, Minimally Invasive
Treatment Outcome
Reg. No./Substance:
0/Enzyme Inhibitors; 61-73-4/Methylene Blue

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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