Document Detail


Intra-operative erythropoietin during laparoscopic partial nephrectomy is not renoprotective.
MedLine Citation:
PMID:  21918797     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: In pre-clinical studies, acute erythropoietin (EPO) administration has been shown to mitigate the deleterious effects of ischemia/reperfusion injury. We reviewed our clinical experience with intraoperative EPO administration as a potential renoprotective agent during laparoscopic partial nephrectomy (LPN). METHODS: Patients who underwent LPN at our institution between August 2008 and March 2010 received 500 IU/kg EPO 30 min prior to hilar occlusion. Those who underwent LPN between August 2006 and July 2008 without receiving EPO were selected as controls. Demographic, clinical, perioperative, and estimated glomerular filtration rate (eGFR) data were compared for the cohorts preoperatively, and during short-term (<6 months) and long-term (≥6 months) follow-up. RESULTS: Short-term eGFR was evaluable for 39 EPO and 29 controls, while long-term eGFR was evaluable for 26 EPO and 27 controls. Baseline demographic and clinical features of the cohorts were similar. For EPO versus controls, median short and long-term follow-up was 19 days versus 22 days and 10.2 months versus 11.9 months, respectively. Mean preoperative, postoperative, and % change in eGFR were statistically similar for the cohorts during short- and long-term follow-up, without and with adjustment for baseline renal function (unadjusted P-values = 0.28, 0.095, and 0.38, respectively, short term, and 0.61, 0.50, and 0.69, respectively, long term). CONCLUSIONS: In this retrospective study, a single dose of EPO prior to hilar occlusion during LPN had no added protective impact on postoperative eGFR in the short or long term. Prospective evaluation in patients with solitary kidneys may better elucidate its potential renoprotective role in this setting.
Authors:
Ephrem O Olweny; Saad A Mir; Samuel K Park; Yung K Tan; Stephen Faddegon; Sara L Best; Cenk Gurbuz; Jeffrey A Cadeddu
Related Documents :
12374927 - An 18-month longitudinal study on a new silicon-based sealer, rsa roekoseal: a leakage ...
18548967 - An up to 20-year retrospective study of 4-unit fixed dental prostheses for the replacem...
11475707 - Plaque removal efficacy of two rotating/oscillating electric toothbrushes.
1068237 - Late results of treatment with partial dentures. an investigation by questionnaire and ...
25420737 - Difference in adenoma detection rates according to colonoscopic withdrawal times and th...
23934387 - Palpation versus ultrasound-guided corticosteroid injections and short-term effect in t...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-15
Journal Detail:
Title:  World journal of urology     Volume:  -     ISSN:  1433-8726     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307716     Medline TA:  World J Urol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Urology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., J8.106, Dallas, TX, 75390, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cloning and characterization of the TneDI restriction-modification system of Thermotoga neapolitana.
Next Document:  Bony impingement limits design-related increases in hip range of motion.