Document Detail

Intra-operative application of real-time tissue elastography for the diagnosis of liver tumours.
MedLine Citation:
PMID:  18331239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Real-time tissue elastography (RTE) has made it possible to visualize tissue elasticity. The aim of this study was to evaluate the usefulness of RTE for the differential diagnosis of liver tumours during surgical exploration. METHODS: Fifty-five liver tumours in 44 patients were examined with RTE, concomitant with routine intra-operative ultrasonography. Elasticity images were classified into four types, from type A (even strain) to type D (no strain), according to the distribution and the degree of the strain contrasted with that of the surrounding liver [elasticity type of liver tumour (ETLT)]. We evaluated the consistency of the findings of RTE with the pathological diagnosis as a reference standard. RESULTS: All malignant lesions showed various degrees of strain reduction in the tumour tissue. Twenty-one of 22 hepatocellular carcinomas (HCCs) were classified as type B with a sensitivity of 95.5%, a specificity of 90.9% and an accuracy of 92.7%, while all 24 metastatic adenocarcinomas were classified as either type C or type D with a sensitivity of 100%, a specificity of 80.6% and an accuracy of 89.1%. CONCLUSION: Application of RTE in surgical exploration provided significant information about the elasticity of liver tumours. RTE, using a new criterion, ETLT, enabled us to distinguish rather accurately between two common malignancies: HCC and metastatic adenocarcinoma.
Koichi Kato; Hiroyuki Sugimoto; Naohito Kanazumi; Shuji Nomoto; Shin Takeda; Akimasa Nakao
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-03-06
Journal Detail:
Title:  Liver international : official journal of the International Association for the Study of the Liver     Volume:  28     ISSN:  1478-3231     ISO Abbreviation:  Liver Int.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-29     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101160857     Medline TA:  Liver Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1264-71     Citation Subset:  IM    
Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Adenocarcinoma / diagnosis*,  surgery,  ultrasonography
Aged, 80 and over
Elasticity Imaging Techniques*
Intraoperative Care
Liver / pathology,  surgery,  ultrasonography
Liver Neoplasms / diagnosis*,  surgery,  ultrasonography
Middle Aged
Prospective Studies

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