Document Detail

Intra-lesional steriod for the management of symptomatic Infantile Digital Fibromatosis.
MedLine Citation:
PMID:  20937573     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Infantile Digital Fibromatosis (IDF) is a benign, often asymptomatic nodular proliferation of fibrous tissue occurring almost exclusively on the extremities. Conventional treatment has included radical surgery but this is associated with a high level of recurrence. Whilst some authors suggest a strictly conservative approach, this is unacceptable when lesions become symptomatic from pain, contracture formation or functional deformity
METHODS: We present a retrospective analysis of 12 symptomatic lesions of which 7 were treated with a novel technique of intra-lesional steroid. From 2004-2009, a total of ten patients received treatment for symptomatic IDFs. Patients were followed-up for an average of 5 years 9 months (range 8-131 months).
RESULTS: Corticosteroid was well tolerated with no significant complications and was associated with lower morbidity that compared with surgery. There was no significance difference between rate of recurrence (1/7 vs. 5/10) for those treated with corticosteroid than compared to those patients who underwent surgery (p=0.3) but the study is underpowered.
CONCLUSIONS: This is the first ever study to look at the role of intra-lesional steroid in the management of IDF. Whilst the majority of asymptomatic Infantile Digital Fibromatoses can be safely observed until natural resolution, intra-lesional corticosteroid is a safe and well-tolerated alternative to surgery for all symptomatic digital fibromatoses of infancy. We suggest it replaces surgery as first-line treatment but look forward to a large multicentre trial to allow comparison.
W J M Holmes; A Mishra; P McArthur
Related Documents :
16253493 - Predictors of symptom recurrence after low-dose inhaled corticosteroid cessation in mil...
11699053 - Decreased osteocalcin levels in patients with chronic obstructive pulmonary disease usi...
24523493 - Asymmetric dimethylarginine and oxidative stress following coronary artery bypass graft...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of plastic, reconstructive & aesthetic surgery : JPRAS     Volume:  64     ISSN:  1878-0539     ISO Abbreviation:  J Plast Reconstr Aesthet Surg     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264239     Medline TA:  J Plast Reconstr Aesthet Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  632-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Department of Plastic Surgery, Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Computational analysis of the structural basis of ligand binding to the crustacean retinoid X recept...
Next Document:  Homogeneous time-resolved fluorescence-based assay to screen for ligands targeting the growth hormon...