| Intra-lesional steriod for the management of symptomatic Infantile Digital Fibromatosis. | |
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MedLine Citation:
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PMID: 20937573 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Infantile Digital Fibromatosis (IDF) is a benign, often asymptomatic nodular proliferation of fibrous tissue occurring almost exclusively on the extremities. Conventional treatment has included radical surgery but this is associated with a high level of recurrence. Whilst some authors suggest a strictly conservative approach, this is unacceptable when lesions become symptomatic from pain, contracture formation or functional deformity METHODS: We present a retrospective analysis of 12 symptomatic lesions of which 7 were treated with a novel technique of intra-lesional steroid. From 2004-2009, a total of ten patients received treatment for symptomatic IDFs. Patients were followed-up for an average of 5 years 9 months (range 8-131 months). RESULTS: Corticosteroid was well tolerated with no significant complications and was associated with lower morbidity that compared with surgery. There was no significance difference between rate of recurrence (1/7 vs. 5/10) for those treated with corticosteroid than compared to those patients who underwent surgery (p=0.3) but the study is underpowered. CONCLUSIONS: This is the first ever study to look at the role of intra-lesional steroid in the management of IDF. Whilst the majority of asymptomatic Infantile Digital Fibromatoses can be safely observed until natural resolution, intra-lesional corticosteroid is a safe and well-tolerated alternative to surgery for all symptomatic digital fibromatoses of infancy. We suggest it replaces surgery as first-line treatment but look forward to a large multicentre trial to allow comparison. |
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Authors:
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W J M Holmes; A Mishra; P McArthur |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of plastic, reconstructive & aesthetic surgery : JPRAS Volume: 64 ISSN: 1878-0539 ISO Abbreviation: J Plast Reconstr Aesthet Surg Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264239 Medline TA: J Plast Reconstr Aesthet Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: 632-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Plastic Surgery, Alder Hey Children's Hospital, Eaton Road, Liverpool L12 2AP, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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