Document Detail


Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program.
MedLine Citation:
PMID:  20387135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Changes in myocardial blood flow between rest and stress states are commonly used to diagnose coronary artery disease. Relative myocardial perfusion imaging (MPI) is used routinely while myocardial blood flow quantification (MBF) may improve the sensitivity for detection of early disease. The ratio of flow at stress and rest (S/R) and their difference (S-R) have both been proposed as a means to detect regions with reduced myocardial flow reserve (MFR). In this study, we describe a highly automated method to calculate regional and global rest, stress, S/R, and S-R polar maps of the left ventricle myocardium.
METHODS: We measured the inter- and intra-operator variability using two randomized datasets (n = 30 each) for each of two operators (novice and expert) with correlation and Bland-Altman reproducibility coefficient (RPC%) analyses.
RESULTS: S-R MBF had less inter-operator dependent variability than S/R (RPC% = 5.0% vs 12.6%, P < .001). While there was no difference in intra-operator variability with S-R MBF (novice vs expert RPC% = 6.4% vs 5.9%, P = ns), variability was higher in the novice-operator for S/R (RPC% = 16.8% vs 8.5% respectively, P < .001), suggesting that S-R may be preferred for detecting small changes in MFR. The novice operator's intervention pattern became more similar to that of the expert in the later dataset, emphasizing the need for adequate training and quality assurance.
CONCLUSION: The proposed method results in low operator-dependent variability, suitable for routine use.
Authors:
Ran Klein; Jennifer M Renaud; Maria C Ziadi; Stephanie L Thorn; Andy Adler; Rob S Beanlands; Robert A deKemp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-13
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  17     ISSN:  1532-6551     ISO Abbreviation:  J Nucl Cardiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  600-16     Citation Subset:  IM    
Affiliation:
University of Ottawa Heart Institute, National Cardiac PET Centre, 40 Ruskin St., Ottawa, ON, K1Y 4W7, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Disease / radionuclide imaging*
Female
Fractional Flow Reserve, Myocardial*
Humans
Image Interpretation, Computer-Assisted / methods*
Male
Myocardial Perfusion Imaging / methods*
Observer Variation
Radiopharmaceuticals / diagnostic use
Reproducibility of Results
Rubidium Radioisotopes / diagnostic use*
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
MIS-100935//Canadian Institutes of Health Research; MOP-79311//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 0/Rubidium Radioisotopes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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