Document Detail


Intra- and inter-beat modeling of cardiovascular dynamics and control: assessing haemodynamic stability and responsiveness.
MedLine Citation:
PMID:  22256306     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In critical care patient management, extensive and invasive patient monitoring is routinely performed in order to quantify patient status in view of therapeutic interventions. Little quantitative integration is performed when collecting information from multiple monitors, and processing algorithms are often based on little physiological understanding. Mechanistic modeling can offer insight into the mechanisms underlying patient stability and sensitivity to alterations in physiological variables. Starting from existing models, we construct an integrated model which combines detailed neural cardiovascular regulation with realistic circulation modeling, using Monte-Carlo techniques for reparameterisation when merging the two models. The combined model is analyzed in terms of its dynamical stability and sensitivity to parameter perturbations under simulated conditions of fluid deficit, anaesthesia, and dilatative cardiomyopathy. The results exemplify how a structural model can serve as a quantitative guide in assessing how different underlying patient states can alter the haemodynamics impact of external therapeutic intervention.
Authors:
Nicola Toschi; Andrea Duggento; Antonio Canichella; Filadelfo Coniglione; Mario Dauri; Alessandro F Sabato; Maria Guerrisi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2011     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2011  
Date Detail:
Created Date:  2012-01-18     Completed Date:  2012-05-31     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8440-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arteries / physiology
Blood Pressure / physiology
Computer Simulation
Electrocardiography
Heart Rate / physiology*
Hemodynamics / physiology*
Humans
Models, Cardiovascular*
Monte Carlo Method

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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