Document Detail

Intra- and extracellular lysosomes in tendon tissue of the mouse after treatment with an anabolic steroid hormone. Ultrastructural and cytochemical study.
MedLine Citation:
PMID:  2718716     Owner:  NLM     Status:  MEDLINE    
Ultrastructural observations of fibroblasts from 6-week-old mouse tendons were carried out at different times after treatment with an anabolic steroid. The characteristic response of the fibroblasts involves the appearance of great numbers of intracellular lysosomes and the emergence of matrix vesicles, some of which could be identified ultrastructurally by their positive reaction for acid phosphatase as extracellular lysosomes. It is suggested that this fine structural gradient after treatment with the anabolic steroid results from, and may be directly the cause of, an increased level of cyclic AMP. The experimental design and the discussion of the findings consider, on the one hand, the use of anabolic steroid hormones in clinical practice and, on the other hand, the appearance of a collagen dysplasia in competitive sports.
H Michna
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anatomica     Volume:  134     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-09     Completed Date:  1989-06-09     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Institut für Anatomie der Medizinischen Universität zu Lübeck, BRD.
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MeSH Terms
Extracellular Space / ultrastructure*
Intracellular Membranes / ultrastructure*
Lysosomes / ultrastructure*
Methandrostenolone / pharmacology*
Mice, Inbred Strains
Microscopy, Electron
Tendons / drug effects,  ultrastructure*
Reg. No./Substance:
0/Hormones; 0/Steroids; 72-63-9/Methandrostenolone

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