Document Detail


Intra- and extracellular lysosomes in tendon tissue of the mouse after treatment with an anabolic steroid hormone. Ultrastructural and cytochemical study.
MedLine Citation:
PMID:  2718716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrastructural observations of fibroblasts from 6-week-old mouse tendons were carried out at different times after treatment with an anabolic steroid. The characteristic response of the fibroblasts involves the appearance of great numbers of intracellular lysosomes and the emergence of matrix vesicles, some of which could be identified ultrastructurally by their positive reaction for acid phosphatase as extracellular lysosomes. It is suggested that this fine structural gradient after treatment with the anabolic steroid results from, and may be directly the cause of, an increased level of cyclic AMP. The experimental design and the discussion of the findings consider, on the one hand, the use of anabolic steroid hormones in clinical practice and, on the other hand, the appearance of a collagen dysplasia in competitive sports.
Authors:
H Michna
Related Documents :
8037696 - Induction of an inactivation pathway for ecdysteroids in larvae of the cotton leafworm,...
16844576 - Effects of growth hormone administration on skeletal muscle glutamine metabolism in sev...
10804236 - Molecular cloning of growth hormone complementary dna in barfin flounder (verasper mose...
4478976 - Studies on the correlation between androgen binding and activation of rat epididymal tu...
22586586 - Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen speci...
2841956 - Changes in lipoxygenase products from synovial fluid in carrageenan induced arthritis i...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anatomica     Volume:  134     ISSN:  0001-5180     ISO Abbreviation:  Acta Anat (Basel)     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-09     Completed Date:  1989-06-09     Revised Date:  2007-07-02    
Medline Journal Info:
Nlm Unique ID:  0370272     Medline TA:  Acta Anat (Basel)     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  57-61     Citation Subset:  IM    
Affiliation:
Institut für Anatomie der Medizinischen Universität zu Lübeck, BRD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Extracellular Space / ultrastructure*
Histocytochemistry
Hormones
Intracellular Membranes / ultrastructure*
Lysosomes / ultrastructure*
Methandrostenolone / pharmacology*
Mice
Mice, Inbred Strains
Microscopy, Electron
Steroids
Tendons / drug effects,  ultrastructure*
Chemical
Reg. No./Substance:
0/Hormones; 0/Steroids; 72-63-9/Methandrostenolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optic nerve sectioning does not affect the development of the retina.
Next Document:  Ontogeny of relationship of middle ear and temporomandibular (squamomandibular) joint in mammals. II...