Document Detail

Intra-atrial tissue plasminogen activator infusion for prosthetic valve thrombosis.
MedLine Citation:
PMID:  16345053     Owner:  NLM     Status:  MEDLINE    
Thrombosis is a well-known and life-threatening complication of prosthetic mechanical valves. Therapy typically requires medical thrombolysis or surgical thrombectomy/valve replacement. We report the case of a thrombosed atrioventricular valve in a young boy with complex congenital heart disease, which was successfully treated with direct intra-atrial infusion of recombinant tissue plasminogen activator after failed attempts at systemic therapy. We present this treatment as an alternative to conventional medical therapy.
Sharon M Seltzer; Michael D Reed; Ernest S Siwik
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  67     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-27     Completed Date:  2006-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-41     Citation Subset:  IM    
Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA.
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MeSH Terms
Fibrinolytic Agents / administration & dosage*
Heart Valve Diseases / drug therapy*
Heart Valve Prosthesis / adverse effects*
Infusions, Intra-Arterial
Thrombolytic Therapy*
Thrombosis / drug therapy*
Tissue Plasminogen Activator / administration & dosage*
Treatment Failure
Reg. No./Substance:
0/Fibrinolytic Agents; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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