| Intra-atrial tissue plasminogen activator infusion for prosthetic valve thrombosis. | |
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MedLine Citation:
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PMID: 16345053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombosis is a well-known and life-threatening complication of prosthetic mechanical valves. Therapy typically requires medical thrombolysis or surgical thrombectomy/valve replacement. We report the case of a thrombosed atrioventricular valve in a young boy with complex congenital heart disease, which was successfully treated with direct intra-atrial infusion of recombinant tissue plasminogen activator after failed attempts at systemic therapy. We present this treatment as an alternative to conventional medical therapy. |
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Authors:
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Sharon M Seltzer; Michael D Reed; Ernest S Siwik |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 67 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-27 Completed Date: 2006-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 139-41 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Case Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Fibrinolytic Agents / administration & dosage* Heart Valve Diseases / drug therapy* Heart Valve Prosthesis / adverse effects* Humans Infusions, Intra-Arterial Male Thrombolytic Therapy* Thrombosis / drug therapy* Tissue Plasminogen Activator / administration & dosage* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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