Document Detail

Intra-articular use of tenoxicam in degenerative osteoarthritis of the knee joint.
MedLine Citation:
PMID:  7895896     Owner:  NLM     Status:  MEDLINE    
Twenty-eight patients, aged 58 years or more and with clinical and radiological evidence of degenerative osteoarthritis of the knee joint, were entered into an open 6-month pilot study. Patients received a single intra-articular injection of tenoxicam (20 mg) into the affected knee with rigid adherence to aseptic technique. Efficacy was assessed in 25 evaluable patients according to three parameters: pain, hydrarthrosis and range of joint movement. Ten days after injection, 40% of patients (10/25) had greatly improved pain, 24% (6/25) showed improvement, while 12% (3/25) experienced a worsening of their pain; the remaining patients (24%) showed no change. Ten days after injection, the percentage of patients with hydrarthrosis was reduced from 43% (12/28) to 20% (5/25). Range of movement of the affected joint 1 month after injection was increased in 60% (15/25) of patients, decreased in 16% (4/25), and unchanged in 24% (6/25). Two patients reported a slight allergic reaction to the injection; no other side-effects were detected. The results of this pilot study justify investigating the efficacy of intra-articular tenoxicam in controlled double-blind studies.
N P Papathanassiou
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  22     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    1994 Nov-Dec
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  332-7     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Injections, Intra-Articular
Knee Joint / radiography*
Middle Aged
Osteoarthritis / drug therapy*,  physiopathology,  radiography
Pain Measurement*
Pilot Projects
Piroxicam / administration & dosage,  analogs & derivatives*,  therapeutic use
Time Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 36322-90-4/Piroxicam; 59804-37-4/tenoxicam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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