Document Detail

Intra-articular sufentanil in multimodal analgesic management after outpatient arthroscopic anterior cruciate ligament reconstruction: a prospective, randomized, double-blinded study.
MedLine Citation:
PMID:  18657739     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This prospective, randomized, blinded study was designed to evaluate the effectiveness of intra-articular sufentanil, ropivacaine, and clonidine compared with that of ropivacaine and clonidine without sufentanil on postoperative pain after arthroscopic reconstruction of the anterior cruciate ligament of the knee. METHODS: One hundred twenty patients were enrolled and randomly divided into 2 groups. At the end of the operation, the surgeon injected 20 mL of a solution containing 5 microg sufentanil, 100 mg ropivacaine, and 1 microg/kg clonidine in the knees of patients in group A whereas the surgeon injected the same solution without sufentanil in group B. During the postoperative period and for the first 24 hours, we recorded pain intensity using a visual analog scale. RESULTS: All patients were discharged after a few hours with well-controlled pain. Pain scores were low in both groups both before and after discharge. We did not show any difference in pain scores at any time point. During the first postoperative hour, patients in group B required more rescue analgesic drugs (P < .05). CONCLUSIONS: In our patients the addition of sufentanil in the intra-articular solution did not provide better control of pain. LEVEL OF EVIDENCE: Level I, therapeutic randomized controlled trial.
Gabriele Armellin; Roberto Nardacchione; Carlo Ori
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2008-05-19
Journal Detail:
Title:  Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association     Volume:  24     ISSN:  1526-3231     ISO Abbreviation:  Arthroscopy     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-28     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506498     Medline TA:  Arthroscopy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  909-13     Citation Subset:  IM    
Institute of Anesthesia and Intensive Care, University of Padua, Padua, Italy.
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MeSH Terms
Ambulatory Surgical Procedures*
Amides / administration & dosage
Analgesics / administration & dosage*,  adverse effects,  therapeutic use
Analgesics, Opioid / administration & dosage*,  adverse effects,  therapeutic use
Anesthetics, Local / administration & dosage
Anterior Cruciate Ligament / surgery*
Clonidine / administration & dosage
Double-Blind Method
Drug Therapy, Combination
Gastrointestinal Diseases / chemically induced
Injections, Intra-Articular
Middle Aged
Pain Measurement
Pain, Postoperative / physiopathology
Patient Readmission / statistics & numerical data
Reconstructive Surgical Procedures* / adverse effects
Sufentanil / administration & dosage*,  adverse effects,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Amides; 0/Analgesics; 0/Analgesics, Opioid; 0/Anesthetics, Local; 4205-90-7/Clonidine; 56030-54-7/Sufentanil; 84057-95-4/ropivacaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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