| Intra-articular injection of high molecular weight hyaluronan after arthrocentesis as treatment for rheumatoid knees with joint effusion. | |
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MedLine Citation:
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PMID: 12172954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to find if a complete synovial fluid aspiration before injection of intra-articular high molecular weight hyaluronan influences the treatment result for knees with rheumatoid arthritis (RA), including joint effusion and the prognostic factors related to clinical effect. METHODS: The arthritic knees including effusion were randomized to arthrocentesis or no arthrocentesis before the hyaluronan (1.9-2.5 x 10(6)) was injected into knee joints five times every week. All patients were followed up for 6 months. RESULTS: One hundred eighteen RA patients (80 knees in the arthrocentesis group, 81 knees in the no-arthrocentesis group) were included. The proportion of no relapses in the arthrocentesis group was higher than that in the no-arthrocentesis group. In the arthrocentesis group, regression analysis showed that duration of knee arthritis (<5 months), CRP (<4 mg/dl), and Larsen grade (<grade II) were the significant predictors. CONCLUSIONS: Arthrocentesis is effective in reducing the risk for arthritis relapse by intra-articular hyaluronan injection to rheumatoid knees with joint effusion. Predicting responders are duration of knee arthritis, CRP, and radiological scores. |
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Authors:
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Nobuyuki Tanaka; Hisashi Sakahashi; Eiichi Sato; Kazuya Hirose; Takumi Ishima; Seiichi Ishii |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial Date: 2002-06-26 |
Journal Detail:
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Title: Rheumatology international Volume: 22 ISSN: 0172-8172 ISO Abbreviation: Rheumatol. Int. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-12 Completed Date: 2003-02-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8206885 Medline TA: Rheumatol Int Country: Germany |
Other Details:
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Languages: eng Pagination: 151-4 Citation Subset: IM |
Affiliation:
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Rheumatology Unit, Sapporo Gorinbashi Orthopedic Hospital in Gorinbashi Hospitals, 2-1, Kawazoe, Minami-ku, Sapporo, Hokkaido, 005-0802, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage* Adult Aged Arthritis, Rheumatoid / complications, diagnosis, drug therapy*, therapy Arthroscopy / methods* Chemotherapy, Adjuvant Combined Modality Therapy Confidence Intervals Female Follow-Up Studies Humans Hyaluronic Acid / administration & dosage* Injections, Intra-Articular Knee Joint / drug effects, physiopathology Logistic Models Male Middle Aged Molecular Weight Odds Ratio Range of Motion, Articular / physiology Reference Values Synovial Fluid / metabolism Synovitis / complications, diagnosis, drug therapy*, therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 9004-61-9/Hyaluronic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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