Document Detail


Intra-articular hyaluronic acid increases cartilage breakdown biomarker in patients with knee osteoarthritis.
MedLine Citation:
PMID:  20101426     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intra-articular hyaluronic acid has been used in treatment of patients with knee osteoarthritis. Though its effect on pain has been well studied, it is not clear how it affects the articular cartilage. This is a preliminary study to evaluate the kinetics of urinary collagen type-II C-telopeptide (CTX-II) as a biomarker of collagen breakdown in response to intra-articular hyaluronic acid injection in patients with symptomatic knee osteoarthritis. Intra-articular injections of hyaluronan were administered to ten patients with symptomatic knee osteoarthritis. Urine collection for urinary CTX-II was obtained at baseline, before each injection and once every other week for a total of 6 months. Urine CTX-II was measured using a CartiLaps(c) ELISA kit. There was a statistically significant increase (p = 0.0136) in CTX-II a week after the third intra-articular injection of hyaluronic acid (6,216 ng/mmol +/- 4,428) compared with baseline (2,233 ng/mmol +/- 1,220). This increase in CTX-II was sustained throughout the entire 6 months follow-up period (repeated measures ANOVA, p < 0.015). This is the first study of changes in an osteoarthritis biomarker after intra-articular hyaluronic acid injections in patients with symptomatic knee osteoarthritis. Contrary to our initial hypothesis that CTX-II levels should decrease after intra-articular hyaluronic acid injections, we found a significant increase in urinary CTX-II levels that was sustained throughout the study. These observations suggest that intra-articular hyaluronic acid injections may accelerate cartilage breakdown in patients with symptomatic knee osteoarthritis. The responsible mechanisms are unknown and warrant further study.
Authors:
Alexandra M Gonzalez-Fuentes; David M Green; Roger D Rossen; Bernard Ng
Related Documents :
6659026 - The ontogeny of acid alpha-naphthyl acetate esterase activity in the thymus.
16781306 - Hypersensitivity reaction to nonanimal stabilized hyaluronic acid.
1137246 - Biochemical characterization of hyaluronic acid from a case of benign, localized, pleur...
22189506 - Gene/protein expression level, immunolocalization and binding characteristics of fatty ...
21816606 - P450-based porous silicon biosensor for arachidonic acid detection.
8972456 - Protection by different agents against inactivation of lipoxygenase by hydrogen peroxide.
Publication Detail:
Type:  Journal Article     Date:  2010-01-27
Journal Detail:
Title:  Clinical rheumatology     Volume:  29     ISSN:  1434-9949     ISO Abbreviation:  Clin. Rheumatol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-27     Completed Date:  2010-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211469     Medline TA:  Clin Rheumatol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  619-24     Citation Subset:  IM    
Affiliation:
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Analysis of Variance
Biological Markers / urine
Cartilage, Articular / metabolism*
Collagen Type II / urine*
Female
Humans
Hyaluronic Acid / therapeutic use*
Injections, Intra-Articular
Male
Middle Aged
Osteoarthritis, Knee / metabolism,  therapy*
Patient Selection
Pilot Projects
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type II; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and stren...
Next Document:  Venous thromboembolism in southern Chinese patients with systemic lupus erythematosus.