| Intra-articular buprenorphine after knee arthroscopy. A randomised, prospective, double-blind study. | |
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MedLine Citation:
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PMID: 9926189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Demonstration of peripheral opioid receptors in inflamed synovia supports the concept of peripheral opioid analgesia. The aim of this study was to evaluate the analgesic effect of intra-articular administration of buprenorphine after knee arthroscopy. METHODS: In a double-blind randomised trial, 48 patients were assigned to four groups: group A patients received buprenorphine 100 micrograms i.a. and NaCl 0.9% i.m., group B patients received bupivacaine 0.25% 50 mg i.a. and NaCl 0.9% i.m., group C patients received NaCl 0.9% i.a. and buprenorphine 100 micrograms i.m., and group D patients received NaCl 0.9% i.a. and NaCl 0.9% i.m. Intensity of postoperative pain was evaluated by VAS at recovery (T0) and 1, 3, 6, 12, 24 h after operation (T1, T2, T3, T4, T5), at rest and during passive 10 degrees knee flexion. Total analgesic requirements and side effects related to study drugs were recorded. RESULTS: The VAS scores were significantly higher in groups C and D than in group A and B patients. The differences were significant at T0, T1, T2 and T3. At T1, group C and D patients had greater analgesic requirement than groups A and B. No patients developed side effects. CONCLUSION: Intra-articular buprenorphine and i.a. bupivacaine, both produced equally good postoperative pain control and allowed a significant reduction of analgesic requirement after knee arthroscopy. |
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Authors:
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G Varrassi; F Marinangeli; A Ciccozzi; G Iovinelli; G Facchetti; A Ciccone |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 43 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: DENMARK |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology, Intensive Care and Pain Management, University of L'Aquila, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / administration & dosage, adverse effects, therapeutic use* Analysis of Variance Anesthetics, Local / administration & dosage, adverse effects, therapeutic use Arthroscopy* / adverse effects Bupivacaine / administration & dosage, adverse effects, therapeutic use Buprenorphine / administration & dosage, adverse effects, therapeutic use* Double-Blind Method Endoscopy* / adverse effects Female Follow-Up Studies Humans Injections, Intra-Articular Injections, Intramuscular Knee Joint / surgery* Male Pain Measurement Pain, Postoperative / drug therapy* Patient Satisfaction Placebos Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anesthetics, Local; 0/Placebos; 2180-92-9/Bupivacaine; 52485-79-7/Buprenorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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