Document Detail

Intra-articular buprenorphine after knee arthroscopy. A randomised, prospective, double-blind study.
MedLine Citation:
PMID:  9926189     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Demonstration of peripheral opioid receptors in inflamed synovia supports the concept of peripheral opioid analgesia. The aim of this study was to evaluate the analgesic effect of intra-articular administration of buprenorphine after knee arthroscopy. METHODS: In a double-blind randomised trial, 48 patients were assigned to four groups: group A patients received buprenorphine 100 micrograms i.a. and NaCl 0.9% i.m., group B patients received bupivacaine 0.25% 50 mg i.a. and NaCl 0.9% i.m., group C patients received NaCl 0.9% i.a. and buprenorphine 100 micrograms i.m., and group D patients received NaCl 0.9% i.a. and NaCl 0.9% i.m. Intensity of postoperative pain was evaluated by VAS at recovery (T0) and 1, 3, 6, 12, 24 h after operation (T1, T2, T3, T4, T5), at rest and during passive 10 degrees knee flexion. Total analgesic requirements and side effects related to study drugs were recorded. RESULTS: The VAS scores were significantly higher in groups C and D than in group A and B patients. The differences were significant at T0, T1, T2 and T3. At T1, group C and D patients had greater analgesic requirement than groups A and B. No patients developed side effects. CONCLUSION: Intra-articular buprenorphine and i.a. bupivacaine, both produced equally good postoperative pain control and allowed a significant reduction of analgesic requirement after knee arthroscopy.
G Varrassi; F Marinangeli; A Ciccozzi; G Iovinelli; G Facchetti; A Ciccone
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  43     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Department of Anaesthesiology, Intensive Care and Pain Management, University of L'Aquila, Italy.
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MeSH Terms
Analgesics, Opioid / administration & dosage,  adverse effects,  therapeutic use*
Analysis of Variance
Anesthetics, Local / administration & dosage,  adverse effects,  therapeutic use
Arthroscopy* / adverse effects
Bupivacaine / administration & dosage,  adverse effects,  therapeutic use
Buprenorphine / administration & dosage,  adverse effects,  therapeutic use*
Double-Blind Method
Endoscopy* / adverse effects
Follow-Up Studies
Injections, Intra-Articular
Injections, Intramuscular
Knee Joint / surgery*
Pain Measurement
Pain, Postoperative / drug therapy*
Patient Satisfaction
Prospective Studies
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Local; 0/Placebos; 2180-92-9/Bupivacaine; 52485-79-7/Buprenorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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