Document Detail

Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis.
MedLine Citation:
PMID:  22724879     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Osteoarthritis (OA) is a progressive disorder of the joints caused by gradual loss of articular cartilage, which naturally possesses a limited regenerative capacity. In the present study, the potential of intra-articular injection of mesenchymal stem cells (MSCs) has been evaluated in six osteoarthritic patients.
METHODS: Six female volunteers, average age of 54.56 years, with radiologic evidence of knee OA that required joint replacement surgery were selected for this study. About 50 ml bone marrow was aspirated from each patient and taken to the cell laboratory, where MSCs were isolated and characterized in terms of some surface markers. About 20-24 × 10(6) passaged-2 cells were prepared and tested for microbial contamination prior to intra-articular injection.
RESULTS: During a one-year follow-up period, we found no local or systemic adverse events. All patients were partly satisfied with the results of the study. Pain, functional status of the knee, and walking distance tended to be improved up to six months post-injection, after which pain appeared to be slightly increased and patients' walking abilities slightly decreased. Comparison of magnetic resonance images (MRI) at baseline and six months post-stem cell injection displayed an increase in cartilage thickness, extension of the repair tissue over the subchondral bone and a considerable decrease in the size of edematous subchondral patches in three out of six patients.
CONCLUSION: The results indicated satisfactory effects of intra-articular injection of MSCs in patients with knee OA.
Mohsen Emadedin; Naser Aghdami; Leila Taghiyar; Roghayeh Fazeli; Reza Moghadasali; Shahrbanoo Jahangir; Reza Farjad; Mohamadreza Baghaban Eslaminejad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-10-29     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  422-8     Citation Subset:  IM    
Department of Regenerative Biomedicine and Cell Therapy, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
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MeSH Terms
Follow-Up Studies
Injections, Intra-Articular
Magnetic Resonance Imaging
Mesenchymal Stem Cell Transplantation*
Middle Aged
Osteoarthritis, Knee / pathology,  therapy*
Transplantation, Autologous

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