| Intra-arterial versus intravenous administration of gastric secretory inhibitors in conscious dogs. Effects of somatostatin, serotonin and isoprenaline on acid and pepsin secretion. | |
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MedLine Citation:
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PMID: 1679013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to evaluate the effects of both intra-arterial and intravenous infusions of somatostatin, serotonin (5-hydroxytryptamine) and isoprenaline beta 1- + beta 2-adrenoceptor agonist) on gastric acid and pepsin secretion in conscious dogs with a gastric fistula. The drugs mentioned have been examined earlier for effects on gastric secretion in vivo during intravenous infusions and these effects could be hampered by the possible indirect mechanism of action as well as the different kinetics of metabolism. A catheter (vascular access port) allowed repeatedly gastric intra-arterial infusions. Somatostatin and serotonin possessed inhibitory effects on gastric acid and pepsin secretion and were without significant differences between the analyzed ways of administration. Intra-arterial infusion, isoprenaline possessed less potent inhibitory effects on gastric secretion: the effects were significant for pepsin secretion but were nonsignificant for acid secretion. The results suggest the mechanism of action of isoprenaline, somatostatin and sertonin to diverge, and for somatostatin and serotonin it was independent of the route of administration. |
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Authors:
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B Johansen; K Bech |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes Volume: 23 ISSN: 0014-312X ISO Abbreviation: Eur Surg Res Publication Date: 1991 |
Date Detail:
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Created Date: 1991-10-03 Completed Date: 1991-10-03 Revised Date: 2006-11-30 |
Medline Journal Info:
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Nlm Unique ID: 0174752 Medline TA: Eur Surg Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 51-7 Citation Subset: IM |
Affiliation:
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Department of Surgical Gastroenterology, Odense University Hospital, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Gastric Acid / secretion Gastric Mucosa / drug effects*, secretion Injections, Intra-Arterial Injections, Intravenous Isoproterenol / administration & dosage* Pentagastrin / pharmacology Pepsin A / secretion Serotonin / administration & dosage* Somatostatin / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 51110-01-1/Somatostatin; 5534-95-2/Pentagastrin; 7683-59-2/Isoproterenol; EC 3.4.23.1/Pepsin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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