| Intra-arterial tissue plasminogen activator: an effective adjunct following microsurgical venous thrombosis. | |
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MedLine Citation:
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PMID: 17992145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluates the efficacy of our protocol using intra-arterial infusion of tissue plasminogen activator (TPA) on free flap salvage following venous thrombosis. A retrospective review was conducted of every free flap performed by a single surgeon since the beginning of his practice. Free flap salvage rates were documented following flap exploration, intra-arterial infusion of TPA, and revision of the venous anastomosis, with or without vein grafting. One hundred twenty-two free tissue transfers were performed from July 2003 through April 2006. Twelve anastomotic complications occurred in 11 flaps (1 arterial thrombosis, 11 venous thromboses). One free muscle flap failed due to arterial thrombosis. All venous thromboses were salvaged using the TPA protocol, although one revision thrombosed on postoperative day 1 and required a second venous revision, leading to its ultimate salvage. We believe that intra-arterial TPA is an effective adjunct in the treatment of microsurgical venous thrombosis and may increase salvage rates following anastomotic complications. |
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Authors:
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William J Casey; Randall O Craft; Alanna M Rebecca; Anthony A Smith; Sung Yoon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of plastic surgery Volume: 59 ISSN: 0148-7043 ISO Abbreviation: Ann Plast Surg Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-09 Completed Date: 2008-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 520-5 Citation Subset: IM |
Affiliation:
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Division of Plastic and Reconstructive Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA. Casey.williamjoseph@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arteries / pathology* Female Humans Mammaplasty / methods Microsurgery / methods* Middle Aged Reconstructive Surgical Procedures / methods Retrospective Studies Skin Transplantation / methods* Surgical Flaps Tissue Plasminogen Activator / metabolism* Venous Thrombosis / drug therapy* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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