Document Detail

Intra-arterial tissue adhesive for medical splenectomy in humans.
MedLine Citation:
PMID:  7019959     Owner:  NLM     Status:  MEDLINE    
Bucrylate (isobutyl 2-cyanoacrylate) was used for the transcatheter embolization of the splenic artery in 4 patients with bleeding gastric varices secondary to splenic vein thrombosis, 3 patients with symptoms of hypersplenism, and 8 patients with bleeding esophageal varices secondary to portal hypertension. The splenic artery was completely occluded in 13 patients and partially occluded in 2. In all but one of the patients, functioning splenic tissue was preserved and no abscess developed. Medical splenectomy with Bucrylate appears to be a safe and effective method for treating bleeding gastric varices secondary to splenic vein thrombosis, and it can alleviate symptoms of hypersplenism. Its role in controlling bleeding from esophageal varices in patients with generalized portal hypertension is worth further study.
M L Goldman; P K Philip; M S Sarrafizadeh; I J Sarfeh; A A Salam; J T Galambos; S R Powers; J A Balint
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Radiology     Volume:  140     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  341-9     Citation Subset:  AIM; IM    
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MeSH Terms
Adhesives / therapeutic use*
Bucrylate / therapeutic use*
Child, Preschool
Clinical Trials as Topic
Cyanoacrylates / therapeutic use*
Embolization, Therapeutic / methods*
Esophageal and Gastric Varices / therapy
Hypersplenism / complications
Hypertension, Portal / complications
Middle Aged
Splenic Artery*
Stomach / blood supply
Thrombophlebitis / complications
Varicose Veins / etiology,  therapy*
Reg. No./Substance:
0/Adhesives; 0/Cyanoacrylates; 1069-55-2/Bucrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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