|Intra-arterial tissue adhesive for medical splenectomy in humans.|
|PMID: 7019959 Owner: NLM Status: MEDLINE|
|Bucrylate (isobutyl 2-cyanoacrylate) was used for the transcatheter embolization of the splenic artery in 4 patients with bleeding gastric varices secondary to splenic vein thrombosis, 3 patients with symptoms of hypersplenism, and 8 patients with bleeding esophageal varices secondary to portal hypertension. The splenic artery was completely occluded in 13 patients and partially occluded in 2. In all but one of the patients, functioning splenic tissue was preserved and no abscess developed. Medical splenectomy with Bucrylate appears to be a safe and effective method for treating bleeding gastric varices secondary to splenic vein thrombosis, and it can alleviate symptoms of hypersplenism. Its role in controlling bleeding from esophageal varices in patients with generalized portal hypertension is worth further study.|
|M L Goldman; P K Philip; M S Sarrafizadeh; I J Sarfeh; A A Salam; J T Galambos; S R Powers; J A Balint|
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|Type: Clinical Trial; Journal Article|
|Title: Radiology Volume: 140 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1981 Aug|
|Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2007-11-15|
Medline Journal Info:
|Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES|
|Languages: eng Pagination: 341-9 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Bucrylate / therapeutic use*
Clinical Trials as Topic
Cyanoacrylates / therapeutic use*
Embolization, Therapeutic / methods*
Esophageal and Gastric Varices / therapy
Hypersplenism / complications
Hypertension, Portal / complications
Stomach / blood supply
Thrombophlebitis / complications
Varicose Veins / etiology, therapy*
|0/Adhesives; 0/Cyanoacrylates; 1069-55-2/Bucrylate|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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