| Intra-arterial tissue adhesive for medical splenectomy in humans. | |
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MedLine Citation:
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PMID: 7019959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bucrylate (isobutyl 2-cyanoacrylate) was used for the transcatheter embolization of the splenic artery in 4 patients with bleeding gastric varices secondary to splenic vein thrombosis, 3 patients with symptoms of hypersplenism, and 8 patients with bleeding esophageal varices secondary to portal hypertension. The splenic artery was completely occluded in 13 patients and partially occluded in 2. In all but one of the patients, functioning splenic tissue was preserved and no abscess developed. Medical splenectomy with Bucrylate appears to be a safe and effective method for treating bleeding gastric varices secondary to splenic vein thrombosis, and it can alleviate symptoms of hypersplenism. Its role in controlling bleeding from esophageal varices in patients with generalized portal hypertension is worth further study. |
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Authors:
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M L Goldman; P K Philip; M S Sarrafizadeh; I J Sarfeh; A A Salam; J T Galambos; S R Powers; J A Balint |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Radiology Volume: 140 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-09-22 Completed Date: 1981-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adhesives
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therapeutic use* Adolescent Adult Aged Bucrylate / therapeutic use* Child Child, Preschool Clinical Trials as Topic Cyanoacrylates / therapeutic use* Embolization, Therapeutic / methods* Esophageal and Gastric Varices / therapy Female Humans Hypersplenism / complications Hypertension, Portal / complications Male Middle Aged Splenectomy Splenic Artery* Stomach / blood supply Thrombophlebitis / complications Varicose Veins / etiology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adhesives; 0/Cyanoacrylates; 1069-55-2/Bucrylate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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