| Intra-arterial thrombolytic therapy of ischaemic complications of lower-limb diabetic angiopathy. | |
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MedLine Citation:
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PMID: 23059602 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Based on the parameters of haemostasis, free radical oxidation and endogenous intoxication the study was aimed at assessing efficacy of intra-arterial administration of urokinase medac in complicated forms of lower-limb diabetic angiopathy. The authors assessed the outcomes of treating a total of 32 patients with complicated forms of lower-limb diabetic angiopathy on the background of basic therapy and 30 patients whose combined therapy included intra-arterial administration of the thrombolytic agent urokinase medac, also studying the indices of haemostasis, endogenous intoxication, free-radical oxidation and antioxidant defence. At admission to hospital, patients were found to have shifts of the coagulogram towards hypercoagulation. The group of patients receiving intra-arterial administration of urokinase showed that the examined parameters on day 20 of treatment as compared with basic therapy alone increased: those of coagulability by 6% (p<0.05), activated partial thromboplastin time by 14% (p<0.01), thrombin time by 9.2% (p<0.01), antithrombin III by 7% (p<0.001). The fibrinogen level decreased by 9% (p<0.05), malonic dialdehyde concentration dropped by 30% (p<0.001), the concentrations of catalase and superoxide dismutase elevated by 55% (p<0.001) and 42%, respectively (p<0.05). The effective concentration of albumin by day 20 increased up to 42.03±0.36 g/L and was by 5% higher as compared with the basic therapy alone (p<0.005). The toxicity index fell to 0.04+0.1 which was by 50% less than after basic therapy. Conclusion. Intra-arterial administration of urokinase medac in treatment of lower-limb diabetic angiopathy considerably normalizes elevated processes of coagulation, accompanied by decreased intensity of free-radical oxidation and followed by elevated concentration of the antioxidant protection enzymes and a decrease in the degree of endogenous intoxication. |
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Authors:
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A N Beliaev; A G Pavelkin; A N Rodin |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery Volume: 18 ISSN: 1027-6661 ISO Abbreviation: Angiol Sosud Khir Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604504 Medline TA: Angiol Sosud Khir Country: - |
Other Details:
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Languages: RUS Pagination: 13-17 Citation Subset: - |
Affiliation:
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Department of General Surgery and Anesthesiology named after N.I. Atyasov Mordovian State University named after N.I. Ogarev, Saransk, Russia. |
Vernacular Title:
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Vnutriarterial'naia tromboliticheskaia terapiia ishemicheskikh oslozhneniĭ diabeticheskoĭ angiopatii konechnosteĭ |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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