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Intra-arterial thrombolytic therapy of ischaemic complications of lower-limb diabetic angiopathy.
MedLine Citation:
PMID:  23059602     Owner:  NLM     Status:  Publisher    
Based on the parameters of haemostasis, free radical oxidation and endogenous intoxication the study was aimed at assessing efficacy of intra-arterial administration of urokinase medac in complicated forms of lower-limb diabetic angiopathy. The authors assessed the outcomes of treating a total of 32 patients with complicated forms of lower-limb diabetic angiopathy on the background of basic therapy and 30 patients whose combined therapy included intra-arterial administration of the thrombolytic agent urokinase medac, also studying the indices of haemostasis, endogenous intoxication, free-radical oxidation and antioxidant defence. At admission to hospital, patients were found to have shifts of the coagulogram towards hypercoagulation. The group of patients receiving intra-arterial administration of urokinase showed that the examined parameters on day 20 of treatment as compared with basic therapy alone increased: those of coagulability by 6% (p<0.05), activated partial thromboplastin time by 14% (p<0.01), thrombin time by 9.2% (p<0.01), antithrombin III by 7% (p<0.001). The fibrinogen level decreased by 9% (p<0.05), malonic dialdehyde concentration dropped by 30% (p<0.001), the concentrations of catalase and superoxide dismutase elevated by 55% (p<0.001) and 42%, respectively (p<0.05). The effective concentration of albumin by day 20 increased up to 42.03±0.36 g/L and was by 5% higher as compared with the basic therapy alone (p<0.005). The toxicity index fell to 0.04+0.1 which was by 50% less than after basic therapy. Conclusion. Intra-arterial administration of urokinase medac in treatment of lower-limb diabetic angiopathy considerably normalizes elevated processes of coagulation, accompanied by decreased intensity of free-radical oxidation and followed by elevated concentration of the antioxidant protection enzymes and a decrease in the degree of endogenous intoxication.
A N Beliaev; A G Pavelkin; A N Rodin
Publication Detail:
Journal Detail:
Title:  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery     Volume:  18     ISSN:  1027-6661     ISO Abbreviation:  Angiol Sosud Khir     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9604504     Medline TA:  Angiol Sosud Khir     Country:  -    
Other Details:
Languages:  RUS     Pagination:  13-17     Citation Subset:  -    
Department of General Surgery and Anesthesiology named after N.I. Atyasov Mordovian State University named after N.I. Ogarev, Saransk, Russia.
Vernacular Title:
Vnutriarterial'naia tromboliticheskaia terapiia ishemicheskikh oslozhneniĭ diabeticheskoĭ angiopatii konechnosteĭ
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