| Intra-arterial thrombolysis for retinal artery occlusion: the Calgary experience. | |
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MedLine Citation:
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PMID: 16408583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Retinal artery occlusion represents a medical emergency with poor prognosis for visual recovery. Spontaneous improvement is estimated to occur in less than 15% of central retinal artery occlusion (CRAO) cases and conventional treatments have provided only limited benefit. Intra-arterial thrombolysis has been reported as a potentially efficacious and safe treatment. METHODS: We performed a retrospective chart review of all retinal artery occlusion cases treated with intra-arterial recombinant tissue-type plasminogen activator (rtPA) from January 1998 to May 2004. Patients received Goldmann perimetry visual field testing at a variable interval following the procedure (2 days-2.5 years). Visual acuity (VA) was re-assessed in May 2004. RESULTS: Eight cases (59-77 years) were treated for CRAO, 6-18 hours post-onset with intra-arterial rtPA (10-20 mg over 15-60 minutes); one case of branch occlusion (BRAO) was treated with 30 mg rtPA over 75 minutes, 12 hours post-onset. Among the six patients with CRAO assessed in clinic, three experienced improvement in VA by two or more gradations (Snellen lines); three improved by one gradation. However, none achieved a final VA better than 20/300. The case of branch occlusion improved to a VA of 20/20. All patients had residual monocular field defects. CONCLUSIONS: Our findings reveal a limited benefit for intra-arterial tPA compared to the rate of spontaneous improvement and conventional forms of therapy for retinal artery occlusion. |
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Authors:
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J A Pettersen; M D Hill; A M Demchuk; W Morrish; M E Hudon; W Hu; J Wong; P A Barber; A M Buchan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques Volume: 32 ISSN: 0317-1671 ISO Abbreviation: Can J Neurol Sci Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2006-01-13 Completed Date: 2006-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0415227 Medline TA: Can J Neurol Sci Country: Canada |
Other Details:
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Languages: eng Pagination: 507-11 Citation Subset: IM |
Affiliation:
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Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Canada Female Humans Male Middle Aged Perimetry Prognosis Retinal Artery Occlusion / diagnosis, drug therapy* Retrospective Studies Thrombolytic Therapy* Time Factors Tissue Plasminogen Activator / therapeutic use* Visual Acuity / physiology Visual Fields |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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