Document Detail

Intra-arterial thrombolysis in basilar artery occlusions combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitors in basilar artery thrombosis.
MedLine Citation:
PMID:  19587474     Owner:  NLM     Status:  MEDLINE    
Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.
S B Gaikwad; M V Padma; E J Moses; Kanika Sethi; M Tripathi; R Bhatia; K Prasad; N K Mishra
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurology India     Volume:  57     ISSN:  0028-3886     ISO Abbreviation:  Neurol India     Publication Date:    2009 May-Jun
Date Detail:
Created Date:  2009-07-09     Completed Date:  2009-10-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0042005     Medline TA:  Neurol India     Country:  India    
Other Details:
Languages:  eng     Pagination:  313-9     Citation Subset:  IM    
Department of Neuroradiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
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MeSH Terms
Basilar Artery / radiography
Cerebral Angiography / methods
Drug Therapy, Combination
Fibrinolytic Agents / administration & dosage*
Intracranial Thrombosis / drug therapy*,  pathology,  radiotherapy
Middle Aged
Platelet Aggregation Inhibitors / administration & dosage*
Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors*
Tissue Plasminogen Activator / administration & dosage*
Tomography, X-Ray Computed / methods
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Platelet Aggregation Inhibitors; 0/Platelet Glycoprotein GPIIb-IIIa Complex; EC Plasminogen Activator

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