| Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit. | |
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MedLine Citation:
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PMID: 6614959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects. |
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Authors:
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R S Surwit; R S Gilgor; M Duvic; L M Allen; J A Neal |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Archives of dermatology Volume: 119 ISSN: 0003-987X ISO Abbreviation: Arch Dermatol Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 733-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brachial Artery Cardiac Output / drug effects* Double-Blind Method Female Heart Rate / drug effects* Humans Injections, Intra-Arterial Male Middle Aged Raynaud Disease / drug therapy* Reserpine / administration & dosage*, adverse effects, therapeutic use Skin Temperature / drug effects Stroke Volume / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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K01-00303//PHS HHS; R01-H1-25547//PHS HHS; RR-30/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-55-5/Reserpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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