Document Detail


Intra-arterial reserpine for Raynaud's syndrome. Systemic reactions without therapeutic benefit.
MedLine Citation:
PMID:  6614959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-four patients classified as having Raynaud's disease or Raynaud's phenomenon were given bilateral brachial artery injections of reserpine or saline in a double-blind fashion. In the six weeks following injection, there was no indication that reserpine produced clinical improvement or changed vasomotor reactivity in the treated patients. However, intra-arterial reserpine did produce systemic cardiovascular effects lasting up to six weeks. It is concluded that intra-arterial reserpine as used in this study is an ineffective treatment for Raynaud's disease or Raynaud's phenomenon and may have significant adverse effects.
Authors:
R S Surwit; R S Gilgor; M Duvic; L M Allen; J A Neal
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of dermatology     Volume:  119     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  733-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brachial Artery
Cardiac Output / drug effects*
Double-Blind Method
Female
Heart Rate / drug effects*
Humans
Injections, Intra-Arterial
Male
Middle Aged
Raynaud Disease / drug therapy*
Reserpine / administration & dosage*,  adverse effects,  therapeutic use
Skin Temperature / drug effects
Stroke Volume / drug effects*
Grant Support
ID/Acronym/Agency:
K01-00303//PHS HHS; R01-H1-25547//PHS HHS; RR-30/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
50-55-5/Reserpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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