Document Detail

Intra-arterial papaverine treatment for cerebral vasospasm: our experience and review of the literature.
MedLine Citation:
PMID:  9631632     Owner:  NLM     Status:  MEDLINE    
We described the techniques and efficacy of intra-arterial papaverine hydrochloride infusion (IA-PAP) for symptomatic vasospasm due to aneurysmal subarachnoid hemorrhage based on our experience and review of the literature. Angiographic improvement occurred almost always, but only 50% of patients who presented with acute symptoms showed remarkable clinical improvement after the first, second, or third IA-PAP. Recurrent vasospasm after IA-PAP frequently occurred and this seems to be an apparent source of controversy regarding its efficacy. Review of the literature indicates that IA-PAP may be most effective in combination with percutaneous transluminal angioplasty. Further controlled studies should be conducted regarding papaverine's true efficacy including most effective papaverine concentration and rate of infusion, maximum total dose, site of infusion, timing of treatment, and selection of patients.
Y Numaguchi; G H Zoarski
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  38     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-09     Completed Date:  1998-07-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
Department of Radiology, University of Rochester Medical Center, New York, USA.
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MeSH Terms
Cerebral Angiography
Injections, Intra-Arterial
Ischemic Attack, Transient / drug therapy*,  radiography
Middle Aged
Papaverine / therapeutic use*
Tomography, X-Ray Computed
Reg. No./Substance:

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