| Intra-arterial papaverine treatment for cerebral vasospasm: our experience and review of the literature. | |
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MedLine Citation:
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PMID: 9631632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We described the techniques and efficacy of intra-arterial papaverine hydrochloride infusion (IA-PAP) for symptomatic vasospasm due to aneurysmal subarachnoid hemorrhage based on our experience and review of the literature. Angiographic improvement occurred almost always, but only 50% of patients who presented with acute symptoms showed remarkable clinical improvement after the first, second, or third IA-PAP. Recurrent vasospasm after IA-PAP frequently occurred and this seems to be an apparent source of controversy regarding its efficacy. Review of the literature indicates that IA-PAP may be most effective in combination with percutaneous transluminal angioplasty. Further controlled studies should be conducted regarding papaverine's true efficacy including most effective papaverine concentration and rate of infusion, maximum total dose, site of infusion, timing of treatment, and selection of patients. |
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Authors:
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Y Numaguchi; G H Zoarski |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Neurologia medico-chirurgica Volume: 38 ISSN: 0470-8105 ISO Abbreviation: Neurol. Med. Chir. (Tokyo) Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-09 Completed Date: 1998-07-09 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0400775 Medline TA: Neurol Med Chir (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 189-95 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Rochester Medical Center, New York, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cerebral Angiography Female Humans Injections, Intra-Arterial Ischemic Attack, Transient / drug therapy*, radiography Middle Aged Papaverine / therapeutic use* Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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58-74-2/Papaverine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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