Document Detail

Intra-arterial nimodipine infusion for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
MedLine Citation:
PMID:  21696654     Owner:  NLM     Status:  MEDLINE    
This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later. Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.
W-S Cho; H-S Kang; J E Kim; O-K Kwon; C W Oh; Y J Son; B J Know; C Jung; M H Hang
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Publication Detail:
Type:  Journal Article     Date:  2011-06-20
Journal Detail:
Title:  Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences     Volume:  17     ISSN:  1591-0199     ISO Abbreviation:  Interv Neuroradiol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-23     Completed Date:  2011-09-14     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  9602695     Medline TA:  Interv Neuroradiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  169-78     Citation Subset:  IM    
Department of Neurosurgery, Kangwon National University Hospital, School of Medicine, Chuncheon, Gangwon-do, Korea.
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MeSH Terms
Calcium Channel Blockers / administration & dosage*,  adverse effects
Cerebral Angiography
Follow-Up Studies
Infusions, Intra-Arterial
Middle Aged
Nimodipine / administration & dosage*,  adverse effects
Retrospective Studies
Subarachnoid Hemorrhage / complications,  drug therapy*,  radiography
Treatment Outcome
Vasospasm, Intracranial / drug therapy*,  etiology,  radiography
Reg. No./Substance:
0/Calcium Channel Blockers; 66085-59-4/Nimodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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