| Intra-arterial nimodipine infusion for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 21696654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later. Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH. |
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Authors:
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W-S Cho; H-S Kang; J E Kim; O-K Kwon; C W Oh; Y J Son; B J Know; C Jung; M H Hang |
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Publication Detail:
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Type: Journal Article Date: 2011-06-20 |
Journal Detail:
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Title: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences Volume: 17 ISSN: 1591-0199 ISO Abbreviation: Interv Neuroradiol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-23 Completed Date: 2011-09-14 Revised Date: 2012-06-19 |
Medline Journal Info:
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Nlm Unique ID: 9602695 Medline TA: Interv Neuroradiol Country: Italy |
Other Details:
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Languages: eng Pagination: 169-78 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Kangwon National University Hospital, School of Medicine, Chuncheon, Gangwon-do, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium Channel Blockers / administration & dosage*, adverse effects Cerebral Angiography Female Follow-Up Studies Humans Infusions, Intra-Arterial Male Middle Aged Nimodipine / administration & dosage*, adverse effects Retrospective Studies Subarachnoid Hemorrhage / complications, drug therapy*, radiography Treatment Outcome Vasospasm, Intracranial / drug therapy*, etiology, radiography |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 66085-59-4/Nimodipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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