Document Detail


Intra-arterial digital subtraction angiography with isotonic dimeric (iodixanol) and monomeric (iohexol) nonionic contrast media: radiographic, clinical and neurophysiological evaluation.
MedLine Citation:
PMID:  7708189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Monomeric (iohexol 300 mg I/ml) and dimeric (iodixanol 270 mg I/ml) nonionic contrast media were compared in a double-blind, randomised, parallel group trial. Safety and efficacy of the media in intra-arterial cerebral digital subtraction angiography were evaluated by assessing adverse events, discomfort, EEG, heart rate and quality of radiodiagnostic information. Seventy-six patients underwent selective injection of the carotid and/or vertebral arteries. Both contrast media were well tolerated. No serious adverse events occurred. No effects on heart rate and EEG were evident. The arteriograms were of high quality and overall diagnostic information was optimal in 94% of the examinations. No clinically important differences between the two contrast media were found.
Authors:
R E Hekster; H H Morré; P Cleyndert; J Zapletal; L F Sinnige; B Bolstad; Y Keetlapper
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neuroradiology     Volume:  37     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-05-09     Completed Date:  1995-05-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  48-50     Citation Subset:  IM    
Affiliation:
Department of Radiology, Leyenburg Hospital, Den Haag, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angiography, Digital Subtraction*
Carotid Artery Diseases / radiography
Cerebral Angiography*
Cerebrovascular Disorders / radiography*
Contrast Media* / adverse effects
Double-Blind Method
Electroencephalography / drug effects*
Female
Heart Rate / drug effects
Humans
Iohexol / adverse effects,  diagnostic use*
Male
Middle Aged
Triiodobenzoic Acids / adverse effects,  diagnostic use*
Vertebrobasilar Insufficiency / radiography
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Triiodobenzoic Acids; 66108-95-0/Iohexol; 92339-11-2/iodixanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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