| Intra-arterial brachytherapy of hepatic malignancies: watch the flow. | |
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MedLine Citation:
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PMID: 20924355 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Although the liver possesses a dual blood supply, arterial vessels deliver only a small proportion of blood to normal parenchyma, but they deliver the vast majority of blood to primary and secondary cancers of the liver. This anatomical discrepancy is the basis for intra-arterial brachytherapy of liver cancers using radioactive microspheres, termed radio-embolization (RE). Radioactive microspheres implant preferentially in the terminal arterioles of tumors. Although biological models of the flow dynamics and distribution of microspheres are currently in development, there is a need to improve the imaging biomarkers of flow dynamics used to plan RE. Since a direct consequence of RE is vascular disruption and necrosis, we suggest that imaging protocols sensitive to changes in vasculature are highly likely to represent useful early biomarkers for treatment efficacy. We propose dynamic contrast-enhanced CT as the most appropriate imaging modality for studying vascular parameters in clinical trials of RE treatment. |
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Authors:
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Bruno Morgan; Andrew S Kennedy; Val Lewington; Bleddyn Jones; Ricky A Sharma |
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Publication Detail:
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Type: Journal Article Date: 2010-10-05 |
Journal Detail:
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Title: Nature reviews. Clinical oncology Volume: 8 ISSN: 1759-4782 ISO Abbreviation: Nat Rev Clin Oncol Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101500077 Medline TA: Nat Rev Clin Oncol Country: England |
Other Details:
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Languages: eng Pagination: 115-20 Citation Subset: IM |
Affiliation:
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Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE1 5WW, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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