Document Detail

Intra-arterial administration of fasudil hydrochloride for vasospasm following subarachnoid hemorrhage - analysis of time-density curve with digital subtraction angiography.
MedLine Citation:
PMID:  17124368     Owner:  NLM     Status:  MEDLINE    
The cerebral circulatory dynamics were evaluated before and after intra-arterial administration of fasudil hydrochloride in 20 patients with angiographic vasospasm after subarachnoid hemorrhage (SAH). The region of interest time-density curves obtained before and after intra-arterial administration of fasudil hydrochloride were compared in the proximal portion of the middle cerebral artery in the early arterial phase, the distal portion of the middle cerebral artery in the late arterial phase, and the transverse sinus in the venous phase. In the early arterial phase, the time to peak and the time to half-peak were significantly reduced. In the late arterial phase and venous phase, the time to peak was significantly reduced. These results suggest that intra-arterial administration of fasudil hydrochloride induced dilation of the proximal arteries, and improved cerebral microcirculation. The present study suggests that intra-arterial administration of fasudil hydrochloride is effective as a treatment for vasospasm following SAH.
Satoshi Iwabuchi; Tetsuya Yokouchi; Morito Hayashi; Hideo Uehara; Morikazu Ueda; Hirotsugu Samejima
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  46     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-24     Completed Date:  2007-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  535-9; discussion 540     Citation Subset:  IM    
The Department of Neurosurgery, Toho University Ohashi Medical Center, Tokyo, Japan.
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MeSH Terms
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / administration & dosage,  analogs & derivatives*
Angiography, Digital Subtraction / methods*
Brain / blood supply,  physiopathology
Cerebral Arteries / drug effects*,  physiopathology,  radiography
Cerebrovascular Circulation / drug effects,  physiology
Contrast Media / pharmacokinetics
Cranial Sinuses / drug effects,  physiopathology,  radiography
Injections, Intra-Arterial / methods,  standards
Middle Aged
Middle Cerebral Artery / drug effects,  physiopathology,  radiography
Subarachnoid Hemorrhage / complications*,  physiopathology
Time Factors
Treatment Outcome
Vasodilation / drug effects,  physiology
Vasodilator Agents / administration & dosage
Vasospasm, Intracranial / drug therapy*,  etiology,  radiography*
Reg. No./Substance:
0/Contrast Media; 0/Vasodilator Agents; 103745-39-7/fasudil; 84477-87-2/1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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