| Intra-arterial Colforsin May Improve the Outcome of Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study. | |
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MedLine Citation:
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PMID: 22120553 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: Papaverine hydrochloride (PPV) has been widely used for pharmacological angioplasty to dilate spastic vessels after aneurysmal subarachnoid hemorrhage (SAH). Colforsin daropate hydrochloride (CDH) has also recently been reported to be useful for reversal of cerebral vasospasm (CV). In this study, we compared the impacts of intra-arterial PPV and CDH on the outcomes of SAH patients. METHODS: A consecutive series of SAH patients were retrospectively analyzed. Ninety-eight and 133 patients were included in the study during 1998-1999 (group A) and 2003-2005 (group B), respectively. PPV or CDH was the only agent used for pharmacological angioplasty in groups A and B, respectively. Good outcome was defined as a modified Rankin scale score ≤2 at discharge. RESULTS: The percentages of patients without CV who had good outcomes were similar in groups A (78%) and B (81%, p=0.91). However, the percentage of patients with CV with a good outcome was significantly higher in group B (66%) than in group A (34%, p=0.032). Logistic regression revealed that age ≤65 years (p=0.0001), World Federation of Neurological Surgeons (WFNS) grade ≤2 (p<0.0001), CV (p=0.0001), and group B (p=0.0069) were independent causative factors for good outcome in the overall patient population. Age ≤65 (p=0.0002) and WFNS grade ≤2 (p<0.0001) were independent causative factors for good outcome in patients without CV, while only group B (p=0.0089) was an independent factor for good outcome in patients with CV. CONCLUSION: CDH appears to be associated with a better outcome in patients with SAH. |
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Authors:
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Satoshi Suzuki; Michiyoshi Sato; Shinzo Ota; Tomoko Fukushima; Akiko Ota; Taisei Ota; Katsuya Goto |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-24 |
Journal Detail:
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Title: World neurosurgery Volume: - ISSN: 1878-8750 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101528275 Medline TA: World Neurosurg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Department of Neurosurgery, Nippon Steel Yawata Memorial Hospital, Kitakyushu, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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