| Intra-arrest rapid head cooling improves postresuscitation myocardial function in comparison with delayed postresuscitation surface cooling. | |
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MedLine Citation:
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PMID: 20449907 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare resuscitation outcomes and myocardial function among intra-arrest head cooling, delayed surface cooling, and uncooled controls. DESIGN: Prospective animal study. SETTING: University-affiliated animal research laboratory. SUBJECTS: Twenty-four male domestic pigs. INTERVENTIONS: Ventricular fibrillation remained untreated for 10 mins after which animals were assigned into three groups: 1) intra-arrest head cooling, 2) postresuscitation surface cooling, and 3) uncooled controls. Head cooling by evaporative perfluorochemical began coincident with the start of cardiopulmonary resuscitation and continued for a total of 4 hrs. Surface cooling using a cooling blanket began at 2 hrs after return of spontaneous circulation and continued for 8 hrs. Control animals were treated identically with the exception for cooling. MEASUREMENTS AND MAIN RESULTS: Return of spontaneous circulation was achieved in eight of eight head-cooled animals, in seven of eight surface-cooled animals, and in seven of eight of controls. Myocardial functions measured by transthoracic echocardiography were significantly better in the head-cooled animals than in surface-cooled and controls. All head-cooled animals survived for more than 96 hrs. This contrasted with six of eight survivors after surface cooling, and only two of eight among controls. CONCLUSIONS: Both intra-arrest head cooling and delayed surface cooling improved postresuscitation myocardial dysfunction. The beneficial effects were greatest with head cooling initiated with cardiopulmonary resuscitation. |
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Authors:
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Min-Shan Tsai; Denise Barbut; Hao Wang; Jun Guan; Shijie Sun; Becky Inderbitzen; Max Harry Weil; Wanchun Tang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care medicine Volume: 36 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2010-05-07 Completed Date: 2010-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: S434-9 Citation Subset: AIM; IM |
Affiliation:
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Weil Institute of Critical Care Medicine, Rancho Mirage, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiopulmonary Resuscitation / methods* Coronary Circulation Echocardiography Electric Countershock / methods* Electrocardiography Epinephrine / administration & dosage Head* Heart Arrest / complications Hypothermia, Induced / methods* Male Respiration, Artificial Swine Vasoconstrictor Agents / administration & dosage Ventricular Fibrillation / etiology, physiopathology, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Vasoconstrictor Agents; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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