Document Detail


Intra-areal and corticocortical circuits arising in the dysgranular zone of rat primary somatosensory cortex that processes deep somatic input.
MedLine Citation:
PMID:  23322443     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Somesthesis-guided exploration of the external world requires cortical processing of both cutaneous and proprioceptive information and their integration into motor commands toguide further haptic movement. In the past, attention has been givenmostlyto thecortical circuits processing cutaneous information for somatic motor integration. By comparison, little has been examined about how cortical circuits are organized for higher-order proprioceptive processing. Using the rat cortex as a model, we characterized the intrinsic and corticocortical circuits arising in the major proprioceptive region of the primary somatosensory cortex (SI) that is conventionally referred to as the dysgranular zone (DSZ). We made small injections of biotinylated dextran amine (BDA) as ananterograde tracer in various parts of the DSZ, revealing three distinct principles of its cortical circuit organization. First, its intrinsic circuits extend mainly along the major axis of DSZ to organize multiple patches of interconnections. Second, the central and peripheral regions of DSZ produce differential patterns of intra-areal and corticocortical circuits. Third, theprojection fields of DSZencompass only selective regions of the second somatic (SII), posterior parietal (PPC), and primary motor (MI) cortices. These projection fields are at least partially separated from those of SI cutaneous areas. Based on these observations, we hypothesize that the cortical circuits of DSZ facilitate a modular integration ofproprioceptive information along its major axisanddisseminatethis informationto only selective parts of higher-order somatic and MIcortices inparallel to cutaneousinformation. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc.
Authors:
Uhnoh Kim; Tae-Hee Lee
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  -     ISSN:  1096-9861     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Wiley Periodicals, Inc.
Affiliation:
Department of Neurosurgery and Interdepartmental Neuroscience Program, Pennsylvania State University, College of Medicine, Hershey, PA 17033. ukim@hmc.psu.edu.
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