| Intra-anal and rectal application of L-erythro methoxamine gel increases anal resting pressure in healthy volunteers. | |
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MedLine Citation:
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PMID: 16231282 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: This study examined the effect of a single local application of L-erythro methoxamine, an alpha(1)-adrenoceptor agonist, on mean anal resting pressure (MARP) and cardiovascular variables in healthy volunteers. METHODS: L-Erythro methoxamine gel was administered in a single-blind manner; 0.3-3 per cent gels were applied perianally (n = 12), 1-3 per cent gels intra-anally (n = 16) and 1 per cent gel rectally (n = 8). MARP, systolic blood pressure, diastolic blood pressure and pulse rate were measured before application and for up to 6 h afterwards. Blood samples were taken to estimate plasma drug levels. RESULTS: Perianal gel produced no increase in MARP. Intra-anal 1 per cent and 3 per cent gel produced a significant rapid rise in MARP for 4 and 5 h respectively after application (P = 0.012 and P = 0.017 respectively). Rectal 1 per cent gel increased MARP for 2 h after application (P = 0.036). Intra-anal gel resulted in an increase in systolic blood pressure (1 per cent gel at 2 h, P = 0.042; 3 per cent gel at 4 h, P = 0.017). One per cent intra-anal and rectal gels caused a decrease in the pulse rate for 2 h after application (P = 0.012 and P = 0.018 respectively). Six subjects complained of nausea and three of headache after gel application. CONCLUSION: Intra-anal and rectal gel produced a sustained rise in MARP with rapid onset in volunteers. This raises the possibility of a therapeutic application for L-erythro methoxamine in patients with passive incontinence and internal anal sphincter dysfunction. |
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Authors:
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P J Nisar; H-J Gruss; D Bush; N Barras; A G Acheson; J H Scholefield |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of surgery Volume: 92 ISSN: 0007-1323 ISO Abbreviation: Br J Surg Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-01 Completed Date: 2006-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372553 Medline TA: Br J Surg Country: England |
Other Details:
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Languages: eng Pagination: 1539-45 Citation Subset: AIM; IM |
Copyright Information:
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Copyright (c) 2005 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. |
Affiliation:
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Section of Surgery, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK. pashanisar@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Rectal Adrenergic alpha-Agonists / pharmacology* Adult Anal Canal / drug effects* Blood Pressure / drug effects Female Gels Humans Male Manometry Methoxamine / administration & dosage, pharmacology* Middle Aged Pressure Pulse Single-Blind Method |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Gels; 390-28-3/Methoxamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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