Document Detail

Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep.
MedLine Citation:
PMID:  12389005     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine whether improved preterm lung function caused by intraamniotic endotoxin treatment requires endotoxin entry into the respiratory tract. STUDY DESIGN: We assessed lung inflammation 2 days after intra-amniotic endotoxin (10 mg, Escherichia coli 055:B5) or saline solution in preterm lambs (123 days' gestation) that had undergone surgery to isolate the gastrointestinal or respiratory systems from the amniotic sac. In other sheep longer-term effects were assessed 7 days after we isolated the fetal respiratory tract and gave endotoxin or saline solution directly to the lungs or into the amniotic sac. We measured pulmonary inflammation, lung function, and surfactant 1 week after treatment (approximately 125 days). RESULTS: Pulmonary inflammation was present after intra-amniotic endotoxin only if there was communication between the respiratory tract and the amniotic sac. Lung function was improved and surfactant was increased only in preterm lambs that received direct pulmonary endotoxin. CONCLUSION: Endotoxin causes functional improvement of the preterm lung by direct effects on the developing respiratory system.
Timothy J M Moss; Ilias Nitsos; Boris W Kramer; Machiko Ikegami; John P Newnham; Alan H Jobe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  187     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-21     Completed Date:  2002-11-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1059-65     Citation Subset:  AIM; IM    
School of Women's and Infants' Health, University of Western Australia, 35 Stirling Highway, Crawley WA, Perth, Australia.
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MeSH Terms
Embryonic and Fetal Development
Endotoxins / administration & dosage,  pharmacology*
Escherichia coli
Fetal Organ Maturity / drug effects
Fetus / physiology
Lung / embryology*
Pneumonia / chemically induced
Pulmonary Surfactants / metabolism
Respiratory System / embryology
Grant Support
Reg. No./Substance:
0/Endotoxins; 0/Pulmonary Surfactants

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