Document Detail

Intra-accumbens infusion of a muscarinic antagonist reduces food intake without altering the incentive properties of food-associated cues.
MedLine Citation:
PMID:  20141279     Owner:  NLM     Status:  MEDLINE    
Previous work has implicated the cholinergic system in modulating feeding behavior; however, its specific function remains unclear. This work aims to characterize potential dissociations between the central cholinergic modulation of the incentive properties of food and food-associated cues, and consummatory behaviors. Three separate experiments demonstrated that intra-accumbens infusion of the muscarinic antagonist scopolamine 3 hr before the testing session significantly decreased food intake. General motor activity in anticipation of food was not diminished. Experiments also showed that scopolamine did not impair operant responding for a food-associated conditioned reinforcer (CR), nor was d-amphetamine potentiation of CR responding altered by scopolamine pretreatment. This study contributes to the growing evidence that goal-seeking behaviors are mediated by a set of neural processes distinct from those governing food reward.
Michelle L Perry; Matthew E Andrzejewski; Susan M Bushek; Brian A Baldo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  124     ISSN:  1939-0084     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-06-28     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  44-54     Citation Subset:  IM    
Copyright Information:
(c) 2009 APA, all rights reserved.
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MeSH Terms
Conditioning, Operant / drug effects
Eating / drug effects*
Feeding Behavior / drug effects
Food Preferences / drug effects
Motivation / drug effects*
Muscarinic Antagonists / pharmacology*
Nucleus Accumbens / drug effects*,  physiology
Rats, Sprague-Dawley
Reaction Time / drug effects
Scopolamine Hydrobromide / pharmacology*
Grant Support
F31DA023775-01A1/DA/NIDA NIH HHS; R01 DA009311/DA/NIDA NIH HHS; R01 DA009311/DA/NIDA NIH HHS; R01 DA009311-12/DA/NIDA NIH HHS; R01 MH074723/MH/NIMH NIH HHS; R37DA004788/DA/NIDA NIH HHS
Reg. No./Substance:
0/Muscarinic Antagonists; 451IFR0GXB/Scopolamine Hydrobromide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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