Document Detail


Intoxications due to ingestion of gamma-butyrolactone: organ distribution of gamma-hydroxybutyric acid and gamma-butyrolactone.
MedLine Citation:
PMID:  18824955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Europe, the misuse of gamma-hydroxybutyric acid (GHB) and its analogues has increased within the recent years. Here, 2 fatalities and 1 nonfatal intoxication resulting from ingestion of gamma-butyrolactone (GBL), a precursor of GHB, are presented. GHB was quantified involving the conversion to GBL by application of a gas chromatography-mass spectrometry (GC/MS) method. Besides quantitation of GHB equivalents ("total GBL"), all specimens of case 1 were analyzed for the metabolic precursor GBL itself (absolute GBL). The cause of death in each case was attributed to GHB intoxication; the manner of death was suicide in the first case and accidental in the second one. Another yet nonfatal GHB intoxication was reported by an emergency department concerning a 36-year-old woman who was hospitalized due to her comatose state and loss of adverse effects reflexes. Here nail polish remover pads were used as source for GBL.
Authors:
Daniel Lenz; Markus A Rothschild; Lars Kröner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  30     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-61     Citation Subset:  IM    
Affiliation:
Institute of Legal Medicine, University of Cologne, Cologne, Germany. daniel.lenz@uk-koeln.de
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MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / adverse effects*,  blood,  pharmacokinetics*
Adult
Brain / metabolism
Female
Humans
Hydroxybutyrates / pharmacokinetics*
Male
Muscle, Skeletal / metabolism
Substance-Related Disorders*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Hydroxybutyrates; 591-81-1/4-hydroxybutyric acid; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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