Document Detail

Intoxications due to ingestion of gamma-butyrolactone: organ distribution of gamma-hydroxybutyric acid and gamma-butyrolactone.
MedLine Citation:
PMID:  18824955     Owner:  NLM     Status:  MEDLINE    
In Europe, the misuse of gamma-hydroxybutyric acid (GHB) and its analogues has increased within the recent years. Here, 2 fatalities and 1 nonfatal intoxication resulting from ingestion of gamma-butyrolactone (GBL), a precursor of GHB, are presented. GHB was quantified involving the conversion to GBL by application of a gas chromatography-mass spectrometry (GC/MS) method. Besides quantitation of GHB equivalents ("total GBL"), all specimens of case 1 were analyzed for the metabolic precursor GBL itself (absolute GBL). The cause of death in each case was attributed to GHB intoxication; the manner of death was suicide in the first case and accidental in the second one. Another yet nonfatal GHB intoxication was reported by an emergency department concerning a 36-year-old woman who was hospitalized due to her comatose state and loss of adverse effects reflexes. Here nail polish remover pads were used as source for GBL.
Daniel Lenz; Markus A Rothschild; Lars Kröner
Related Documents :
14969555 - Fatty acid content and juice characteristics in black currant (ribes nigrum l.) genotypes.
15466585 - A single amino acid substitution converts gamma-glutamyltranspeptidase to a class iv ce...
6295795 - The dual effects of gaba and related amino acids on the electrical threshold of ventral...
2862605 - Interoceptive stimuli produced by an anxiogenic drug are mimicked by benzodiazepine ant...
189155 - Regulation of fatty acid biosynthesis in ehrlich cells by ascites tumor plasma lipoprot...
21121265 - Nutritional value of the chilean seaweeds cryptonemia obovata and rhodymenia corallina.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  30     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-05     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  755-61     Citation Subset:  IM    
Institute of Legal Medicine, University of Cologne, Cologne, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
4-Butyrolactone / adverse effects*,  blood,  pharmacokinetics*
Brain / metabolism
Hydroxybutyrates / pharmacokinetics*
Muscle, Skeletal / metabolism
Substance-Related Disorders*
Tissue Distribution
Reg. No./Substance:
0/Hydroxybutyrates; 591-81-1/4-hydroxybutyric acid; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Therapeutic drug monitoring of ziprasidone in a clinical treatment setting.
Next Document:  An HPLC-PDA method for the simultaneous quantification of the HIV integrase inhibitor raltegravir, t...