Document Detail

Intoxication delirium following use of synthetic cathinone derivatives.
MedLine Citation:
PMID:  22783894     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In published reports of hallucinatory delirium following use of "bath salts" analytic laboratory testing has demonstrated the synthetic cathinone derivative methylenedioxypyrovalerone (MDPV). MDPV can cause a false-positive screening immunoassay result for phencyclidine (PCP). Patients using MDPV are prone to development of the syndrome of excited delirium (ExD), a condition also described with PCP.
OBJECTIVE: This review summarize reports from several series of cases of delirium associated with MDPV emphasizing the features of both intoxication and excited delirium.
METHODS: Literature review and clinical description of a series of patients from Eastern North Carolina.
CONCLUSION: MDPV is likely the responsible agent in production of both toxic and excited delirium syndromes identified with the recreational use of "bath salts" in the United States over the past two years.
SCIENTIFIC SIGNIFICANCE: Patients using MDPV are prone to the development of toxic delirum with some developing ExD. a condition associated with considerable risk for serious medical morbidity. Commonly used interventions directed at extreme agitation and paranoia may exacerbate the pathophysiology of ExD.
Thomas M Penders; Richard E Gestring; Dmitry A Vilensky
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Publication Detail:
Type:  Comment; Letter     Date:  2012-07-11
Journal Detail:
Title:  The American journal of drug and alcohol abuse     Volume:  38     ISSN:  1097-9891     ISO Abbreviation:  Am J Drug Alcohol Abuse     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-03-08     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  7502510     Medline TA:  Am J Drug Alcohol Abuse     Country:  England    
Other Details:
Languages:  eng     Pagination:  616-7     Citation Subset:  IM    
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MeSH Terms
Delirium / chemically induced*
Designer Drugs*
Methamphetamine / analogs & derivatives*
Psychoses, Substance-Induced / diagnosis*
Street Drugs*
Reg. No./Substance:
0/Designer Drugs; 0/Street Drugs; 44RAL3456C/Methamphetamine
Comment On:
Am J Drug Alcohol Abuse. 2012 Mar;38(2):176-80   [PMID:  22221190 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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