Document Detail

Into the intracellular logistics of cross-presentation.
MedLine Citation:
PMID:  22566915     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The induction of cytotoxic CD8(+) T cell responses requires the presentation of antigenic peptides by MHC class I molecules (MHC I). MHC I usually present peptides derived from endogenous proteins. However, some subtypes of dendritic cells have developed the ability to efficiently present peptides derived from exogenous antigens on MHC I via a process called cross-presentation. Cross-presentation is intimately linked to the induction of anti-viral, -bacterial, and -tumor cytotoxic T cell (CTL) responses, as well as a wide variety of CTL-mediated diseases and transplant rejections. The molecular and cellular mechanisms underlying cross-presentation have been studied intensively since its original description, yet understanding of this process is incomplete and on the forefront of immunological research. Numerous pathways and models, some of them conflicting, have been described so far. Here, we review the various pathways reported as involved in cross-presentation, highlighting the complexity of this process. We also discuss in detail the different intracellular steps required, from antigen capture and routing, to processing, and finally peptide loading, emphasizing the need for a better understanding of the cell biology of this phenomenon.
Jacques Neefjes; Charlotte Sadaka
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Publication Detail:
Type:  Journal Article     Date:  2012-02-28
Journal Detail:
Title:  Frontiers in immunology     Volume:  3     ISSN:  1664-3224     ISO Abbreviation:  Front Immunol     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  2012-08-23     Revised Date:  2013-08-13    
Medline Journal Info:
Nlm Unique ID:  101560960     Medline TA:  Front Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  31     Citation Subset:  -    
Division of Cell Biology, The Netherlands Cancer Institute Amsterdam, Netherlands.
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