| Intimal hyperplasia in mouse vein grafts is regulated by flow. | |
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MedLine Citation:
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PMID: 15608438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Altered flow conditions are presumed to cause stenosis in vein grafts due to exaggerated neointimal formation. The aim of this study was to establish a mouse model of flow-regulated intimal hyperplasia (IH) in vein grafts. The caval vein was grafted into the common carotid artery of 38 mice, followed by modulation of the blood flow, resulting in vein grafts with high (HF) and low flow (LF). The vessel wall thickening was evaluated after 3, 14 and 42 days by morphometric analyses and immunohistochemistry. There was an immediate significant change in flow, which was persistent throughout the time of observation. After 42 days, flow was increased 2.7 times in HF animals compared to LF animals. The vessel wall was composed of two layers where the inner layer was positive for alpha-actin and considered as IH. The area of neointimal formation was 74% larger in the LF group compared to the HF group. The present study demonstrates that flow regulates IH in vein grafts in mice. This model gives the potential to study the effect of shear stress on vascular biology in genetically modified animals. |
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Authors:
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Klas Osterberg; Erney Mattsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-17 |
Journal Detail:
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Title: Journal of vascular research Volume: 42 ISSN: 1018-1172 ISO Abbreviation: J. Vasc. Res. Publication Date: 2005 Jan-Feb |
Date Detail:
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Created Date: 2005-01-25 Completed Date: 2005-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9206092 Medline TA: J Vasc Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 13-20 Citation Subset: IM |
Affiliation:
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Wallenberg Laboratory for Cardiovascular Research, Department of Vascular Surgery, Sahlgrenska Academy, Goteborg University, Göteborg, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Count Cell Division Hyperplasia Male Mice Mice, Inbred C57BL Muscle, Smooth, Vascular / pathology Regional Blood Flow Shear Strength Tunica Intima / pathology* Veins / pathology, physiology, transplantation* |
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