| Intimal hyperplasia and coronary flow reserve after heart transplantation: association with big endothelin-1. | |
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MedLine Citation:
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PMID: 12490270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Endothelin, a peptide with strong vasoconstrictive and mitogenic properties, has been found to increase after cardiac transplantation. We therefore assessed the association between its precursor peptide, big endothelin-1, and intimal hyperplasia and coronary flow reserve after heart transplantation. METHODS: Thirty-five patients without hemodynamically significant coronary artery disease after heart transplantation were investigated: Average peak flow velocity in the left anterior descending artery (LAD) was assessed by intracoronary Doppler at baseline as well as after injection of adenosine; coronary flow reserve was calculated as a ratio of both and was corrected for patient age and baseline average peak flow velocity. Lumen, intima + media and total vessel area were measured by intracoronary ultrasound. The plasma concentration of big endothelin-1 in venous blood was determined by radioimmunoassay. RESULTS: Patients with elevated big endothelin-1 levels (>2 fmol/ml) tended to have a decreased corrected coronary flow reserve (2.60 +/- 0.9 vs 3.21 +/- 1.0, p = 0.078). They also had a significantly larger intima + media area (5.82 +/- 2.9 vs 2.37 +/- 2.9 mm(2), p = 0.004) and total vessel area (18.36 +/- 5.8 vs 12.81 +/- 4.8 mm(2), p = 0.012) than those with normal plasma concentrations. CONCLUSIONS: Our study suggests an association between elevated big endothelin-1 plasma levels and the development of intimal hyperplasia and reduction of coronary flow reserve after cardiac transplantation. |
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Authors:
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Paul Wexberg; Richard Pacher; Suzanne Rödler; Katharina Kiss; Gilbert Beran; Michael Grimm; Gerald Maurer; Dietmar Glogar |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation Volume: 21 ISSN: 1053-2498 ISO Abbreviation: J. Heart Lung Transplant. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-19 Completed Date: 2003-03-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102703 Medline TA: J Heart Lung Transplant Country: United States |
Other Details:
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Languages: eng Pagination: 1257-63 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine II, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. paul.wexberg@univie.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biological Markers / blood Cohort Studies Coronary Angiography Coronary Circulation / physiology Coronary Disease / diagnosis*, epidemiology, physiopathology Endothelin-1 / analysis, blood* Female Heart Transplantation / adverse effects, methods* Hemodynamics / physiology Humans Hyperplasia / pathology, ultrasonography Male Middle Aged Predictive Value of Tests Prevalence Probability Radioimmunoassay Risk Assessment Sensitivity and Specificity Severity of Illness Index Tunica Intima / pathology*, ultrasonography Ultrasonography, Doppler Ultrasonography, Interventional |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelin-1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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