Document Detail


Intestinally derived lipids: metabolic regulation and consequences--an overview.
MedLine Citation:
PMID:  18693144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Various dietary factors affect postprandial metabolism yet precise mechanisms have not necessarily been pinpointed. The effects of various meal components on postprandial lipemia lead to the following question: do we need a standardized oral lipid tolerance test? A number of transporters, enzymes, receptors and hormones directly influence and act as "gatekeepers" of these processes. Each protein appears to have specific and individual functional roles in the overall process and selected developments in these areas will be reviewed. Within the intestinal cells, FABP2 (fatty acid-binding protein 2) and MTP (microsomal triglyceride transfer protein) are required for the formation of chylomicrons. Niemann-Pick C1-like 1 (NPC1-L1) plays an important role in cholesterol absorption and provides a pharmacological target. Hormones such as GLP1 and GLP2 influence this absorption process. Within the periphery, lipoprotein lipase (LPL) is a key gatekeeper of clearance. Of the massive amounts of fatty acids released by LPL, 36% escape peripheral adipose and muscle uptake and fatty acid overload can result in LPL product inhibition. Acylation stimulating protein (ASP) and insulin are two key hormones in maintaining efficient tissue uptake and re-esterification of fatty acids while TNFalpha negatively influences this process. In both ASP deficient (C3 KO) and C5L2 KO mice, postprandial lipemia increased with reduced adipose tissue storage. This is compensated by increased energy expenditure and muscle lipid oxidation. Clearance of hepatic remnants is controlled through many factors, including SR-B1 and ABCA1. Intestinal, peripheral and hepatic gatekeepers serve important and individual roles in regulating postprandial lipemia and provide potential targets for regulation.
Authors:
Katherine Cianflone; Sabina Paglialunga; Christian Roy
Related Documents :
10985414 - Acetyl-coa carboxylase and fatty acid synthase activity and immunodetectable protein in...
17350584 - Novel fucogangliosides found in human colon adenocarcinoma tissues by means of glycomic...
6422484 - A new explanation for the progressive tissue loss in electrical injuries.
11753754 - In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis b...
3989384 - Preparation of gm1 ganglioside molecular species having homogeneous fatty acid and long...
6148254 - Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cime...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-08-06
Journal Detail:
Title:  Atherosclerosis. Supplements     Volume:  9     ISSN:  1567-5688     ISO Abbreviation:  Atheroscler Suppl     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100973461     Medline TA:  Atheroscler Suppl     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, McGill University, Montreal, Canada. katherine.cianflone@crhl.ulaval.ca
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Carrier Proteins / metabolism*
Dyslipidemias / metabolism*
Fatty Acid-Binding Proteins / metabolism*
Fatty Acids / metabolism
Humans
Intestinal Absorption / physiology*
Intestines / metabolism*
Microsomes
Postprandial Period / physiology*
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/FABP2 protein, human; 0/Fatty Acid-Binding Proteins; 0/Fatty Acids; 0/microsomal triglyceride transfer protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanism of the reflex inhibition of heart rate elicited by acupuncture-like stimulation in anesthe...
Next Document:  The intestine as a regulator of cholesterol homeostasis in diabetes.